Side Effects of trifluoperazine: A Synthesis of Findings from 22 Studies

  1. Home
  2. Side Effects of trifluoperazine
This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Side Effects of trifluoperazine: A Synthesis of Findings from 22 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Side Effects of trifluoperazine: A Synthesis of Findings from 22 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to DatasetPlease check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Major Findings

Trifluoperazine is a conventional antipsychotic medication that is effective in treating mental illnesses such as schizophrenia, but it can also cause various side effects. This article introduces the main research findings on the side effects of trifluoperazine.

Reasons for Side Effects

Trifluoperazine exerts its effects by antagonizing dopamine receptors. Dopamine is a neurotransmitter involved in various brain functions such as movement, thinking, and mood. Inhibition of dopamine receptors can affect these brain functions. This is considered to be the main reason why trifluoperazine causes side effects. ,

Common Side Effects

Extrapyramidal Symptoms

Trifluoperazine can cause side effects called extrapyramidal symptoms. This is because inhibition of dopamine receptors causes abnormalities in motor control. Extrapyramidal symptoms include tremor, rigidity, akathisia, and dystonia. 7 , 11 , 2

Neuroleptic Malignant Syndrome

Trifluoperazine can cause a rare but serious side effect called neuroleptic malignant syndrome. Neuroleptic malignant syndrome is characterized by symptoms such as high fever, muscle rigidity, impaired consciousness, and increased blood pressure. Neuroleptic malignant syndrome can be life-threatening, so it is important to start treatment early. 11 , 2

Others

Trifluoperazine can cause various side effects in addition to extrapyramidal symptoms and neuroleptic malignant syndrome. Other common side effects include drowsiness, dizziness, dry mouth, constipation, and weight gain. 7 , 12 , 2 , 6

Countermeasures for Side Effects

Extrapyramidal Symptoms

Extrapyramidal symptoms can be reduced by adjusting the dosage of trifluoperazine or by co-administering drugs such as anticholinergics. 20

Neuroleptic Malignant Syndrome

Neuroleptic malignant syndrome requires discontinuation of trifluoperazine and appropriate treatment. Neuroleptic malignant syndrome can be life-threatening, so it is important to start treatment early. 11

Others

Other side effects can be reduced by adjusting the dosage of trifluoperazine or by improving lifestyle. 7 , 12 , 2 , 6

Comparison of Studies

Common Points of Studies

Many studies have shown that trifluoperazine is an effective treatment, while it can cause various side effects. It has also been suggested that many of the side effects are caused by inhibition of dopamine receptors. , , 7 , 11 , 2 , 12 , 6 , 20

Differences Between Studies

The type and severity of side effects caused by trifluoperazine may vary depending on the study. For example, some studies report extrapyramidal symptoms while others report neuroleptic malignant syndrome. This may be due to differences in the patient population or research methods used. , , 7 , 11 , 2 , 12 , 6 , 20

Precautions for Real-Life Applications

Trifluoperazine is an effective medication for mental illnesses, but it can cause various side effects. When taking trifluoperazine, it is important to understand the risks of side effects and to follow your doctor's instructions. If you notice any side effects, consult your doctor immediately. , , 7 , 11 , 2 , 12 , 6 , 20

Limitations of Current Research

Research on the side effects of trifluoperazine is not yet sufficient. In particular, research on long-term side effects is lacking. Therefore, the long-term effects of trifluoperazine are not yet fully understood. , , 7 , 11 , 2 , 12 , 6 , 20

Future Research Directions

Further research on the side effects of trifluoperazine is needed. In particular, research on long-term side effects and research to elucidate the mechanisms of side effect occurrence are important. These studies may reveal safer ways to use trifluoperazine. , , 7 , 11 , 2 , 12 , 6 , 20

Conclusion

Trifluoperazine is an effective medication for mental illnesses, but it can cause various side effects. When taking trifluoperazine, it is important to understand the risks of side effects and to follow your doctor's instructions. If you notice any side effects, consult your doctor immediately. It is hoped that future research will provide further insights into the side effects of trifluoperazine.

Literature analysis of 22 papers
Positive Content
16
Neutral Content
2
Negative Content
4
Article Type
1
3
3
3
22
1.

Double-blind crossover comparison of triazolam and lorazepam in the posthypnotic state.

Author: CohnJ B

Induces sleep
Daytime sleepiness
Side effects

Triazolam and lorazepam are both effective hypnotics, but lorazepam has more pronounced daytime carryover and side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Zuclopenthixol dihydrochloride for schizophrenia.

Author: BryanEdward J, PurcellMarie Ann, KumarAjit

Treat psychotic symptoms
Extra-pyramidal reactions
Insulin/glucose response modification
Neuroleptic malignant syndrome
QTc interval prolongation
Venous thromboembolism

This abstract provides information about the anti-psychotic medication zuclopenthixol dihydrochloride (Clopixol) and its potential side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

3.

Comparing effectiveness of risperidone with first-generation antipsychotic medications in patients with schizophrenia-spectrum disorders.

Author: LiewAlvin, VermaSwapna, Lye Yin Poon, EdimansyahAbdin, SubramaniamMythily, VaingankarJanhavi, Siow Ann Chong

Improved tolerability

This retrospective study compared the effectiveness of risperidone, a second-generation antipsychotic, with first-generation antipsychotics (haloperidol and trifluoperazine) in patients with first-episode schizophrenia-spectrum disorders. Risperidone was associated with a longer time to discontinuation, particularly due to side effects.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

4.

Trifluoperazine versus low-potency first-generation antipsychotic drugs for schizophrenia.

Author: TardyMagdolna, DoldMarkus, EngelRolf R, LeuchtStefan

Schizophrenia treatment
Side effects

Antipsychotic drugs are the core treatment for schizophrenia. Low-potency antipsychotics are often perceived as less efficacious than high-potency drugs, but they also have different side-effect profiles.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

5.

Antipsychotic medication for early episode schizophrenia.

Author: BolaJohn, KaoDennis, SoydanHaluk

Schizophrenia treatment

Many people with early-onset schizophrenia are treated with antipsychotic medications for a long period, but how these medications affect the course of the illness in the short and long term is not fully understood. Research suggests that people with early-onset schizophrenia may respond differently to treatment compared to those with multiple previous episodes. This suggests that the number of episodes a person has experienced might influence how well they respond to medications.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

6.

Psychotropic drugs interfere with the tight coupling of polyphosphoinositide cycle metabolites in human platelets: a result of receptor-independent drug intercalation in the plasma membrane?

Author: OruchRamadhan, HodnelandErlend, PrymeIan F, HolmsenHolm

Membrane intercalation

This study investigated the effects of antipsychotic drugs on the polyphosphoinositide (PPI) cycle in platelets. The study found that these drugs interfere with the tight coupling of PPI cycle metabolites, which may explain their psychotropic actions.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

The psychotropic drug olanzapine (Zyprexa) increases the area of acid glycerophospholipid monolayers.

Author: SteinkopfSigne, SchelderupAnja Katrin, GjerdeHanne Linn, PfeifferJeanette, ThoresenSynnøve, GjerdeAnja Underhaug, HolmsenHolm

Atypical antipsychotic
Side effects

This study investigated the effects of olanzapine and chlorpromazine on glycerophospholipid monolayers. Olanzapine was found to have a greater effect on monolayer packing than chlorpromazine, suggesting that the two drugs may interact with lipids differently.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

The effects of the atypical antipsychotics clozapine, remoxipride and risperidone on the contractile characteristics of rat skeletal muscle in vitro.

Author: MendesL S, CollinsS P

Reduced extrapyramidal side-effects
Muscle contracture

Clozapine, remoxipride, and risperidone did not induce contracture in rat skeletal muscle in vitro, while trifluoperazine and haloperidol did.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

11.

Risperidone, neuroleptic malignant syndrome and probable dementia with Lewy bodies.

Author: SechiG, AgnettiV, MasuriR, DeianaG A, PugliattiM, PaulusK S, RosatiG

Neuroleptic malignant syndrome

This study reported a rare familial case of probable Dementia with Lewy bodies (DLB) who experienced neuroleptic malignant syndrome (NMS) after exposure to risperidone and trifluoperazine. Discontinuation of risperidone and increased dopaminergic therapy led to recovery.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

12.

Blinking-blepharospasm after long-term neuroleptic treatment.

Author: SachdevP S

Blepharospasm

A patient developed frequent blinking and blepharospasm after long-term treatment with trifluoperazine, a neuroleptic drug. The condition improved after discontinuation of the drug, suggesting a role of dopaminergic mechanisms in this side effect.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

Clinical modulation of doxorubicin resistance by the calmodulin-inhibitor, trifluoperazine: a phase I/II trial.

Author: MillerR L, BukowskiR M, BuddG T, PurvisJ, WeickJ K, ShepardK, MidhaK K, GanapathiR

Acquired resistance
Cancer treatment
Extrapyramidal effects

The combination of trifluoperazine and doxorubicin was well-tolerated in patients with doxorubicin resistance. Trifluoperazine did not affect doxorubicin toxicity but may enhance its efficacy, especially in patients with acquired resistance.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

Treatment of Gilles de la Tourette's syndrome: eight-year, practice-based experience in a predominantly adult population.

Author: MesulamM M, PetersenR C

Tourette's syndrome treatment
Drug side effects

Over 86% of 58 patients with Tourette's syndrome achieved effective control of their symptoms with dopamine-blocking neuroleptics. These medications are often effective but may require frequent adjustments or rotations due to side effects. Clonidine, another medication, was less effective in treating motor and vocal tics.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

15.

Combined MAO-inhibitor and tri- (tetra) cyclic antidepressant treatment in therapy resistant depression.

Author: SchmaussM, KapfhammerH P, MeyrP, HoffP

Effective for therapy resistant depression
Safe when properly administered
Unusual toxicity

A combination of tranylcypromine and tri- (tetra) cyclic antidepressants was effective in treating therapy-resistant depression. The combination was generally safe and well-tolerated.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

16.

Effective short-term treatment of generalized anxiety disorder with trifluoperazine.

Author: MendelsJ, KrajewskiT F, HufferV, TaylorR J, SecundaS, SchlessA, SebastianJ A, SemchyshynG, DurrM J, MelmedA S

Anxiety treatment

Trifluoperazine (2-6 mg daily) was evaluated in 415 outpatients with generalized anxiety disorder. Trifluoperazine significantly improved anxiety compared to placebo. The side effects profile of trifluoperazine and placebo were similar.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

17.

Radio receptor assay of serum neuroleptic levels in psychiatric patients.

Author: KrskaJ, SampathG, ShahA, SoniS D

Useful for monitoring neuroleptic treatment

The radioreceptor assay for the measurement of neuroleptic drugs in serum was found to be reproducible and capable of detecting neuroleptics in the sera of patients receiving a range of both oral and depot drugs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

Comparative chronic effects of buspirone or neuroleptics on rat brain dopaminergic neurotransmission.

Author: McMillenB A

Free of extrapyramidal side effects

Buspirone, a novel anti-anxiety drug, had no effect on dopaminergic function in rats.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

20.

Treatment approaches in Gilles de la Tourette syndrome.

Author: BorisonR L, AngL, HamiltonW J, DiamondB I, DavisJ M

Amantadine efficacy
Tourette syndrome treatment
Tardive dyskinesia

Haloperidol is often used to treat Tourette syndrome but has numerous side effects, including tardive dyskinesia. Fluphenazine and trifluoperazine were found to be equally effective as haloperidol with fewer side effects. Clonidine was also equally effective with fewer central nervous system side effects. Amantadine was more effective than benztropine in treating the extrapyramidal side effects of haloperidol treatment. Lithium did not significantly reduce tics.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

21.

Inhibited female orgasm resulting from psychotropic drugs. A clinical review.

Author: ShenW W, SataL S

Orgasm inhibition

Psychotropic drugs, including antipsychotics, MAOIs, and tricyclic antidepressants, can inhibit female orgasm. Physicians should be aware of this underreported sexual side effect.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.