Pharmacodynamic and pharmacokinetic study of oral and intravenous penbutolol.

Author: MaassL, PetersonL E, VedinJ A, WilhelmssonC

Paper Details 
Original Abstract of the Article :
The present study was done to establish the dose-response relationships for effects on heart rate and systolic and diastolic blood pressure, tolerance and plasma disappearance kinetics after large intravenous and oral doses of penbutolol. Twelve healthy volunteers were randomly allocated to receive ...See full text at original site
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引用元:
https://doi.org/10.1007/BF00542123

データ提供:米国国立医学図書館(NLM)

Penbutolol: A Versatile Tool for Managing Heart Rate and Blood Pressure

The human heart, like a tireless camel, beats continuously, pumping blood throughout the body. This study investigates the effects of penbutolol, a medication used to regulate heart rate and blood pressure, on the cardiovascular system.

The study delves into the pharmacodynamic and pharmacokinetic properties of penbutolol, exploring its effects on heart rate, blood pressure, and its elimination from the body. This is like understanding the camel's stamina, its tolerance for different environments, and how it replenishes its energy.

The researchers found that penbutolol, both intravenously and orally, effectively lowered heart rate and blood pressure. This is like a skilled camel handler using a combination of techniques to regulate the camel's pace and ensure a safe and efficient journey.

The study also showed that penbutolol was well tolerated by participants, indicating its safety and effectiveness. This is like finding a reliable oasis that provides refreshment without causing any adverse effects.

Penbutolol: A Promising Solution for Cardiovascular Management

The study showcases the potential of penbutolol as a valuable tool for managing heart rate and blood pressure. It's like discovering a new water source that can help quench the thirst of the body and keep the caravan moving smoothly.

Understanding Penbutolol's Effects on the Cardiovascular System

The study's findings provide valuable insights into penbutolol's effects on the cardiovascular system. It's like learning more about the camel's physiology and how its body adapts to different conditions.

Dr. Camel's Conclusion

This research, like a compass guiding us through the desert of cardiovascular health, sheds light on the potential of penbutolol in managing heart rate and blood pressure.

Date :
  1. Date Completed 1984-02-14
  2. Date Revised 2019-08-13
Further Info :

Pubmed ID

6653649

DOI: Digital Object Identifier

10.1007/BF00542123

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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