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A comparison of buprenorphine and pethidine for immediate postoperative pain relief by the i.v. route.

Author: GeddesI C, KamelM M

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Buprenorphine was found to be effective in relieving pain after surgery in patients with lower abdominal incisions. It was found to provide analgesia for four times longer than pethidine. Vomiting, drowsiness and dizziness were less common with buprenorphine, although nausea occurred at similar rates.
Paper Details　
Original Abstract of the Article :
A comparison was made of the relief of pain after operation, obtained following the i.v. administration of buprenophrine and pethidine in 60 patients with lower abdominal incisions. No difference could be detected between the maximum analgesia produced by eigher drug, but analgesia following bupreno...See full text at original site
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://doi.org/10.1093/bja/50.6.599

データ提供：米国国立医学図書館（NLM）

Buprenorphine vs. Pethidine: A Tale of Two Pain Relievers

The quest for effective postoperative pain relief is like navigating a desert of discomfort. This research compares the effectiveness of [buprenorphine] and [pethidine] in alleviating pain after lower abdominal incisions. The authors conducted a rigorous study to determine which agent reigns supreme in this battle against pain.

Long-Lasting Relief with Buprenorphine

The study found that both [buprenorphine] and [pethidine] provided comparable levels of pain relief, but [buprenorphine] offered a significantly longer duration of action. Think of it like a camel with a large water reservoir, providing a sustained supply of relief, while [pethidine] is like a smaller, more fleeting oasis. This longer-lasting relief could translate to improved patient comfort and reduced pain medication requirements.

Navigating the Side Effect Desert

The study also examined the side effects of both medications. While both drugs can cause nausea, [buprenorphine] was associated with fewer instances of vomiting, drowsiness, and dizziness. This means that patients may experience a smoother and more manageable recovery journey with [buprenorphine] compared to [pethidine].

Dr.Camel's Conclusion

This study sheds light on the relative effectiveness of [buprenorphine] and [pethidine] in managing postoperative pain. Like a seasoned traveler choosing the best route through the desert, this research helps guide clinicians toward a more effective and less burdensome path for their patients.

Date :
  1. Date Completed 1978-09-29
  2. Date Revised 2022-03-16
Further Info :

Pubmed ID

666936

DOI: Digital Object Identifier

10.1093/bja/50.6.599

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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