Side Effects of buprenorphine injection (pain relief): A Synthesis of Findings from 30 Studies

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This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Side Effects of buprenorphine injection (pain relief): A Synthesis of Findings from 30 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

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Original Abstract of the Article

Major Research Findings

Buprenorphine is an effective drug for pain relief, but it can cause some side effects. A study 14 found that repeated injections of buprenorphine in mice led to increased activity, disrupted circadian rhythm, and abnormal behaviors. The study also found that mice experienced decreased food and water intake and body weight loss. However, these side effects were less frequent when buprenorphine was given as a sustained-release formulation. Another study 15 found that high doses of tramadol given to mice in drinking water negatively impacted their water intake, drinking frequency, food intake, and body weight. However, buprenorphine given to mice in drinking water did not have any adverse health effects. These studies suggest that while buprenorphine is effective for pain relief, it can cause side effects depending on the administration method and dosage. It is important to understand the risk of side effects and choose the appropriate administration method when giving buprenorphine.

Reasons for Side Effects

Buprenorphine is an opioid drug that works by acting on opioid receptors in the brain to suppress pain. However, opioid receptors are also present in the respiratory center and digestive system, so buprenorphine can also act on these organs, causing side effects.

Common Side Effects

Respiratory Depression

Buprenorphine can suppress the respiratory center and reduce the breathing rate. Respiratory depression is more likely to occur when buprenorphine is administered in excess or to patients with respiratory diseases. 10 reported that respiratory depression was observed in patients who received buprenorphine, but it was not at a clinically significant level.

Gastrointestinal Symptoms

Buprenorphine can suppress the digestive system and cause side effects such as constipation, nausea, and vomiting. 12 found that side effects such as nausea and vomiting were observed in patients who received buprenorphine.

Psychoneurological Symptoms

Buprenorphine can act on the central nervous system, causing side effects such as drowsiness, dizziness, hallucinations, and delirium. 14 found that mice that received repeated injections of buprenorphine showed an increase in activity, disrupted circadian rhythm, and a tendency towards abnormal behavior.

Dependence

Buprenorphine is said to have a lower risk of dependence and abuse than other opioid drugs such as morphine. 8 suggests that buprenorphine is as effective as morphine as an analgesic, but with a lower risk of dependence.

Measures to Counteract Side Effects

Countermeasures for Respiratory Depression

It is important to closely monitor the patient's respiratory status when administering buprenorphine. If the breathing rate decreases or becomes shallow, the dose should be reduced or the administration stopped.

Countermeasures for Gastrointestinal Symptoms

It is important to drink enough fluids and eat a diet high in fiber to prevent constipation. If nausea or vomiting is severe, an antiemetic should be taken.

Countermeasures for Psychoneurological Symptoms

If drowsiness or dizziness occurs, driving or operating dangerous machinery should be avoided. If symptoms such as hallucinations or delirium occur, consult a doctor.

Countermeasures for Dependence

Buprenorphine is said to have a lower risk of dependence and abuse than other opioid drugs such as morphine. However, buprenorphine is not completely free of the risk of dependence. If buprenorphine is used long-term, it is necessary to follow the doctor's instructions and adjust the dosage as needed.

Comparison between Studies

Commonalities between Studies

Multiple studies have shown that buprenorphine is effective for pain relief, while it can cause some side effects.

Differences between Studies

The frequency and severity of side effects have been shown to vary depending on the administration method and dosage of buprenorphine. For example, repeated injections of buprenorphine have been shown to cause side effects more frequently than sustained-release formulations.

Precautions for Application in Real Life

Buprenorphine is an effective drug for pain relief, but it is important to understand the risk of side effects and choose the appropriate administration method. When taking buprenorphine, follow the doctor's instructions and do not stop taking it or adjust the dosage on your own.

Limitations of Current Research

Research on buprenorphine is still not sufficient. More research is needed, especially on the side effects of long-term use of buprenorphine and its interactions with other drugs.

Directions for Future Research

Further research on buprenorphine is needed. In particular, more detailed research is needed on the side effects of long-term use of buprenorphine and its interactions with other drugs. More research is also needed on the optimal administration methods to maximize the effects of buprenorphine while minimizing side effects.

Conclusion

Buprenorphine is an effective drug for pain relief, but it can cause some side effects. It is important to understand the risk of side effects and choose the appropriate administration method when administering buprenorphine. More research on buprenorphine is needed.

Keywords
Benefit Keywords
Reduced allergic rhinitis symptoms
1
Effective for seasonal rhinitis
Mild side effects
2
Analgesic potency
Less nausea
Longer duration
3
Fast pain relief
Good analgesia
No respiratory depression
Stable cardiovascular
4
Effective anesthesia
Improved analgesia
Reduced opioid use
Reduced side effects
5
Pain relief
6
Pain management
Postoperative analgesia
7
Effective analgesic
Less addictive potential
Safe alternative to morphine
8
Pain relief
9
Cost saving
Good analgesia
10
Cancer pain relief
11
Effective pain relief
12
Postoperative analgesia
Reduced anesthetic requirement
13
Pain relief
14
Pain relief
15
Pain relief
16
Pain relief
Reduced respiratory depression
17
Postoperative analgesia
18
Decreased opioid requirements
Improved analgesia
Patient control
19
Pain relief
20
Postoperative pain relief
21
Pain relief
Reduced sedation
22
Faster recovery
Improved pain management
Reduced lidocaine dose
23
Pain relief
24
Pain relief
25
long-lasting pain relief
pain relief
reduced side effects
26
Effective treatment
Well tolerated
27
Long-lasting analgesia
Pain relief
29
Longer analgesia duration
Reduced postoperative pain
30
Risk Keywords
Postoperative sedation
3
More frequent side effects
4
Limited duration
Neurotoxicity
5
Septicemia
6
Emesis
Nausea
Sweating
7
Side effects
9
Respiratory depression
10
Ineffective pain treatment
Poor tolerability
11
Nausea
Vomiting
12
Pruritus
13
Side effects
Stress response
14
Pruritus
Urinary retention
16
Drowsiness
Nausea
Pruritus
Vomiting
17
Respiratory depression
18
Respiratory depression
19
Dizziness
20
Cranial cruciate ligament rupture
21
Increased heart rate
22
Hematuia
Hypotension
23
Side effects
24
Sedation
Side effects
25
Gastrointestinal side effects
27
CDIC
28
Dizziness
Drowsiness
Miosis
Nausea
Vomiting
29
Headache
Nausea
30
Literature analysis of 30 papers
Positive Content
28
Neutral Content
1
Negative Content
1
Article Type
11
1
1
3
30
1.

Budesonide in grass pollen rhinitis.

Author: NormanP S, CreticosP S, TobeyR, ProudD G, Kagey-SobotkaA, MeyersD A, PerssonT

Reduced allergic rhinitis symptoms

Budesonide nasal spray was found to be significantly more effective than placebo in treating seasonal allergic rhinitis. Patients receiving budesonide had a greater reduction in symptoms of sneezing, stuffy nose, and nasal secretion. There was no difference in eye itch or rescue medication use between the two groups.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Budesonide - a new steroid for intranasal use. A double-blind clinical comparison between budesonide and placebo in patients with seasonal allergic rhinitis.

Author: WarlandA, MøllerP, LindqvistN

Effective for seasonal rhinitis
Mild side effects

Budesonide nasal spray was more effective than placebo in treating seasonal rhinitis in 29 patients. Side effects were mild and infrequent.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

A comparison of buprenorphine and pentazocine for the relief of postoperative pain.

Author: FreedmanM

Analgesic potency
Less nausea
Longer duration
Postoperative sedation

Buprenorphine (0.3 mg and 0.6 mg) and pentazocine (30 mg and 60 mg) were compared in 100 patients following orthopaedic surgery. Buprenorphine was more potent and had a longer duration of action than pentazocine. Buprenorphine was associated with less nausea, vomiting, and euphoria, but a higher incidence of sedation.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

4.

Epidural sufentanil versus intramuscular buprenorphine for postoperative analgesia. A double-blind comparative trial.

Author: DonadoniR, RollyG

Fast pain relief
Good analgesia
No respiratory depression
Stable cardiovascular
More frequent side effects

Epidural sufentanil was found to be more effective than intramuscular buprenorphine in providing faster pain relief after surgery, suggesting its potential for managing postoperative pain.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Upper extremity nerve block: how can benefit, duration, and safety be improved? An update.

Author: BrattwallMetha, JildenstålPether, Warrén StombergMargareta, JakobssonJan G

Effective anesthesia
Improved analgesia
Reduced opioid use
Reduced side effects
Limited duration
Neurotoxicity

Ultrasound-guided upper extremity blocks are useful for providing anesthesia and postoperative analgesia. Continuous perineural infusion can prolong the effects and improve postoperative quality.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

6.

Pain treatment on outpatient basis utilizing extradural opiates. A Danish multicentre study comprising 105 patients.

Author: CrawfordMichael E, AndersenHans B, AugustenborgGeorg, BayJørgen, BeckOle, BenvenisteDaniel, LarsenLars B, CarlPeder, DjernesMogens, EriksenJørgen, GrellAnne Marie, HenriksenHans, JohansenSophus H, JørgensenHans O K, MøllerI W, PedersenJens E P, RavloOdd

Pain relief
Septicemia

Extradural opiates provided effective pain relief in patients with malignant and benign diseases, with a low incidence of serious side effects. Outpatient management was feasible.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

7.

[Postoperative on-demand analgesia with buprenorphine].

Author: LehmannK A, GördesB

Pain management
Postoperative analgesia
Emesis
Nausea
Sweating

Patient-controlled analgesia (PCA) using buprenorphine was highly effective and well-accepted by patients recovering from surgery. PCA provided superior pain relief compared to traditional methods, with only minor side effects such as sweating, nausea, and vomiting.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : German

8.

Buprenorphine and morphine efficacy in postoperative pain: a double-blind multiple-dose study.

Author: OuelletteR D

Effective analgesic
Less addictive potential
Safe alternative to morphine

Buprenorphine and morphine were found to be equally effective in relieving pain in post-surgical patients in a double-blind study involving 97 patients. Buprenorphine may be a safer alternative to morphine for acute pain due to its lower addictive potential.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

10.

A double-blind comparison of the relative efficacy, side effects and cost of buprenorphine and morphine in patients after cardiac surgery.

Author: RabinovM, RosenfeldtF L, McLeanA J

Cost saving
Good analgesia
Respiratory depression

Buprenorphine injections were found to be as effective as morphine infusions in relieving pain and respiratory depression in 13 patients after cardiac surgery. Buprenorphine was significantly cheaper to administer than morphine.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

Buprenorphine for treating cancer pain.

Author: Schmidt-HansenMia, BromhamNathan, TaubertMark, ArnoldStephanie, HilgartJennifer S

Cancer pain relief
Ineffective pain treatment
Poor tolerability

This Cochrane review aims to assess whether buprenorphine is associated with superior, inferior or equal pain relief and tolerability compared to other analgesic options for patients with cancer pain.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

12.

Sublingual buprenorphine and pethidine for immediate postoperative pain relief in major gynecologic surgery: a comparative study.

Author: TungphaisalS, ChandeyingV, SutthijumroonS, AeuwpadungS

Effective pain relief
Nausea
Vomiting

Sublingual buprenorphine provided longer-lasting pain relief than intramuscular pethidine after gynecologic surgery, but its onset of action was slower. Both treatments caused nausea and vomiting.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

13.

[Effect of intrathecal administration of opioid on minimum alveolar concentration and postoperative pain relief--a comparison of morphine and buprenorphine].

Author: NishimiY, YonemuraE, MiwaY, FukushimaK

Postoperative analgesia
Reduced anesthetic requirement
Pruritus

Intrathecal buprenorphine (BPN) was found to have a dose-dependent effect on decreasing the MAC of halothane and providing mild analgesia without significant side effects, while intrathecal morphine (Mor) was associated with severe pruritus.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Japanese

14.

Buprenorphine for pain relief in mice: repeated injections vs sustained-release depot formulation.

Author: JirkofP, TourvieilleA, CinelliP, ArrasM

Pain relief
Side effects
Stress response

This study compared a sustained-release formulation of buprenorphine with a standard protocol of three injections of buprenorphine in mice.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

15.

Administration of Tramadol or Buprenorphine via the drinking water for post-operative analgesia in a mouse-osteotomy model.

Author: JirkofPaulin, DurstMattea, KlopfleischRobert, PalmeRupert, Thöne-ReinekeChrista, ButtgereitFrank, Schmidt-BleekKatharina, LangAnnemarie

Pain relief

This study evaluated the effectiveness of two painkillers, tramadol and buprenorphine, in mice with a bone injury. Tramadol was found to be less effective than buprenorphine, and high doses of tramadol had negative effects on the mice's well-being.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

16.

Epidural buprenorphine for postoperative analgesia. A controlled comparison with epidural morphine.

Author: WolffJ, CarlP, CrawfordM E

Pain relief
Pruritus
Urinary retention

Epidural buprenorphine 0.3 mg and epidural morphine 4 mg were compared in a double-blind study for postoperative pain relief. Both groups achieved satisfactory analgesia. Buprenorphine's duration of action was 620 minutes, while morphine's was 580 minutes. Serious side effects were observed only in the morphine group, with two patients experiencing pruritus and five experiencing urinary retention.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

17.

[Postoperative analgesia after cesarean section: sublingual buprenorphine versus subcutaneous morphine].

Author: AbidA, BenhamouD, LabailleT

Pain relief
Reduced respiratory depression
Drowsiness
Nausea
Pruritus
Vomiting

Sublingual buprenorphine and subcutaneous morphine were equally effective in controlling postoperative pain after Caesarean section, with minimal respiratory depression and similar side effect profiles.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : French

18.

[Influence of intrathecal morphine and buprenorphine on EEG and their analgesic effect].

Author: YonemuraE, ShimadaM, NakamuraM, FukushimaK

Postoperative analgesia
Respiratory depression

Intrathecal morphine (M) was found to be more effective than intrathecal buprenorphine (B) in providing postoperative analgesia for patients undergoing gynecological surgery. Morphine provided pain relief for 12 hours, while buprenorphine provided pain relief for 6 hours.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Japanese

19.

[Patient-controlled analgesia].

Author: ScherpereelP

Decreased opioid requirements
Improved analgesia
Patient control
Respiratory depression

Patient-controlled analgesia (PCA) is a drug delivery system that allows patients to self-administer pain medication. It improves analgesia and decreases opioid requirements, providing both behavioral and decisional control for patients. However, risks include opioid side-effects, mainly respiratory depression, due to mechanical problems, machine failure, or user incidents.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : French

20.

Intramuscular on demand analgesia: double blind controlled trial of pethidine, buprenorphine, morphine, and meptazinol.

Author: HarmerM, SlatteryP J, RosenM, VickersM D

Pain relief
Dizziness

An on-demand intramuscular analgesic system using Cardiff Palliator was tested in 40 patients after cholecystectomy. Most patients achieved good pain relief, similar to intravenous analgesia. Buprenorphine provided the longest-lasting analgesia and lowest pain scores. The system is a simple and effective way to manage postoperative pain.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

22.

Mandatory sublingual buprenorphine for postoperative pain.

Author: BullinghamR E, O'SullivanG, McQuayH J, PoppletonP, RolfeM, WeirL, MooreR A

Pain relief
Reduced sedation
Increased heart rate

Buprenorphine premedication for postoperative pain after total hip replacement improved pain scores but was not significantly better than morphine or placebo. A higher pulse rate was observed in patients receiving buprenorphine.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

24.

Comparative evaluation of intramuscular buprenorphine, pentazocine and nefopam in post-operative pain relief.

Author: SidhuB S, KhichyS, SinghK H

Pain relief
Side effects

The study compared the pain relief effects of three injectable analgesics, buprenorphine, pentazocine, and nefopam, in 75 postoperative patients. All drugs were administered intramuscularly.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

25.

Comparison of analgesic activity of buprenorphine hydrochloride and morphine in patients with moderate to severe pain postoperatively.

Author: OuelletteR D

Pain relief
Sedation
Side effects

Buprenorphine was found to be comparable to morphine in terms of analgesic activity and side effects in patients with moderate to severe postoperative pain. Both drugs showed similar onset, duration of action, and side effect liability.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

26.

[The benefit of combining spinal morphine and intravenous buprenorphine for perioperative pain].

Author: Ben-AbrahamR, BeltruttiD, NivD, WeinbroumA

long-lasting pain relief
pain relief
reduced side effects

This study evaluated the perioperative antinociceptive effects of concurrent administration of morphine and buprenorphine in women undergoing hysterectomy. Concomitant administration of intrathecal morphine and low dose intravenous buprenorphine produced better and longer pain relief than intravenous buprenorphine alone.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Hebrew

28.

Continuous infusion of opioid and bupivacaine by externalized intrathecal catheters in long-term treatment of "refractory" nonmalignant pain.

Author: NitescuP, DahmP, AppelgrenL, CurelaruI

CDIC

Continuous intrathecal infusion of bupivacaine and opioid provided pain relief for 95% of patients with intractable nonmalignant pain. The treatment resulted in increased nocturnal sleep duration, reduced nonopioid analgesic consumption, and minimal changes in gait and ambulation. Long-term treatment failure occurred in 34% of patients. The most common side effects included transient paresthesia, short-lasting paresis, temporary urine retention, and orthostatic hypotension.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

29.

A comparison of buprenorphine and pethidine for immediate postoperative pain relief by the i.v. route.

Author: KamelM M, GeddesI C

Long-lasting analgesia
Pain relief
Dizziness
Drowsiness
Miosis
Nausea
Vomiting

Buprenorphine was found to be effective in relieving pain after surgery in patients with lower abdominal incisions. It was found to provide analgesia for four times longer than pethidine. Vomiting, drowsiness and dizziness were less common with buprenorphine, although nausea occurred at similar rates.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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