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Kinetics of epsilon-aminocaproic acid distribution, elimination, and antifibrinolytic effects in normal subjects.
Author: AtkinsonA J, BowsherD J, FrederiksenM C, GreenD, HenthornT K, RuoT I, Ts'aoC H
Original Abstract of the Article :
The kinetics of epsilon-aminocaproic acid (EACA) distribution and elimination were studied in six normal subjects after a single 10-gm iv dose. Steady-state distribution volume averaged 30.01 or 0.39 l/kg. Mean elimination t 1/2 was 294 min and the elimination clearance was 0.19 l/min. Renal excreti...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
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* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1038/clpt.1984.48
データ提供:米国国立医学図書館(NLM)
Epsilon-Aminocaproic Acid: A Lifeline in the Desert of Hemorrhage
[Epsilon-aminocaproic acid (EACA)] is a medication commonly used to control [fibrinolysis], a process that can lead to excessive bleeding, like a sudden sandstorm that can disrupt the fragile balance of a desert ecosystem. This study examines the pharmacokinetic profile of EACA, exploring how this medication is absorbed, distributed, and eliminated from the body, like studying the flow of water through a desert landscape. Understanding these processes is crucial for optimizing EACA's effectiveness and minimizing potential side effects.
Understanding EACA's Journey: A Pharmacokinetic Exploration
The study found that [EACA is primarily eliminated through renal excretion] and its antifibrinolytic effect is closely tied to its plasma concentration. This is like tracing the path of a river through a desert, observing how water flows, evaporates, and eventually reaches its destination. By understanding the kinetics of EACA, healthcare providers can better manage its use and ensure its effectiveness in controlling bleeding.
Navigating the Desert of Bleeding Control
This research provides valuable information for healthcare professionals managing patients with bleeding disorders. It highlights the importance of considering pharmacokinetic factors when prescribing medications, like understanding the unique characteristics of a desert environment before embarking on a journey. By carefully navigating the desert of medication use, healthcare providers can optimize treatment outcomes and ensure the well-being of their patients.
Dr. Camel's Conclusion
This study provides a detailed roadmap for understanding the pharmacokinetics of EACA, guiding healthcare professionals in optimizing its use for bleeding control. The findings underscore the importance of considering individual patient factors and tailoring treatment plans to achieve the best possible outcome.
Date :
- Date Completed 1984-04-17
- Date Revised 2019-05-11
Further Info :
Related Literature
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