Effects of echothiophate on enzymatic hydrolysis of dipivefrin.

Author: AndersonJ A, MindelJ S, RichmanJ B

Paper Details 
Original Abstract of the Article :
Dipivefrin is an antiglaucoma prodrug that is hydrolyzed to the active drug, epinephrine, by esterases in the cornea. Since cholinergic antiglaucoma agents are frequently used in combination with adrenergic agents, it was of interest to determine the effects of a commonly used irreversible cholinest...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://doi.org/10.1001/archopht.1984.01040030733032

データ提供:米国国立医学図書館(NLM)

Echothiophate's Effects on Dipivefrin Hydrolysis: A Detailed Examination

Glaucoma, a condition affecting eye pressure, is often treated with medications like dipivefrin, a prodrug that is converted to the active drug epinephrine in the cornea. This study investigates the effects of echothiophate, a cholinesterase inhibitor commonly used in glaucoma treatment, on the hydrolysis of dipivefrin. The researchers used in vitro and in vivo models to assess the interaction between these drugs, uncovering a complex interplay that impacts the effectiveness of dipivefrin therapy.

Understanding Drug Interactions in Glaucoma Treatment

This research is like a careful examination of the desert ecosystem – a delicate balance between different organisms. The study reveals that echothiophate can act as a reversible inhibitor of dipivefrin hydrolysis, influencing the effectiveness of dipivefrin in treating glaucoma. This information is crucial for ophthalmologists to optimize treatment strategies for patients with glaucoma, ensuring the best possible outcomes.

Navigating the Complexities of Glaucoma Treatment

Glaucoma treatment can be like navigating a desert – complex, with diverse factors influencing the effectiveness of therapies. Understanding the interactions between drugs like echothiophate and dipivefrin is crucial for optimizing treatment. By considering these interactions, clinicians can tailor treatment plans to achieve better outcomes for patients with glaucoma.

Dr.Camel's Conclusion

This research provides valuable insights into the interactions between echothiophate and dipivefrin, highlighting the importance of carefully considering drug interactions in glaucoma treatment. It's like understanding the intricate connections within a desert ecosystem – a delicate balance that requires careful observation and consideration.

Date :
  1. Date Completed 1984-07-10
  2. Date Revised 2019-07-04
Further Info :

Pubmed ID

6732575

DOI: Digital Object Identifier

10.1001/archopht.1984.01040030733032

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.