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Multimodal treatment in operable breast cancer: five-year results of the CMF programme.

Author: BonadonnaG, RossiA, ValagussaP, VeronesiU

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Adjuvant chemotherapy with cyclophosphamide, methotrexate, and fluorouracil (CMF) significantly improved relapse-free survival (59.5% vs. 44.6%) and total survival (78.4% vs. 66.2%) in patients with breast cancer compared to radical mastectomy alone. The benefits were associated with the number of diseased axillary nodes and the amount of drug administered. The chemotherapy had moderate and reversible side effects with no observed chronic organ damage or increased second neoplasms.
Paper Details　
Original Abstract of the Article :
The five-year results of a prospective randomised trial of radical mastectomy (179 patients) versus radical mastectomy followed by adjuvant chemotherapy (207 patients) were analysed. Chemotherapy consisted of 12 monthly cycles of cyclophosphamide, methotrexate, and fluorouracil (CMF). Both relapse-f...See full text at original site
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引用元：
https://doi.org/10.1136/bmj.282.6274.1427

データ提供：米国国立医学図書館（NLM）

Multimodal Treatment for Breast Cancer: A Multi-Pronged Approach

The fight against [breast cancer] is a complex one, often requiring a [multimodal approach]. This study presents the five-year results of a [prospective randomized trial] comparing [radical mastectomy] with [radical mastectomy followed by adjuvant chemotherapy (CMF)]. The researchers found that [both relapse-free survival and total survival were significantly improved] in the [CMF group]. The results highlight the benefits of a multimodality approach in [breast cancer] treatment, demonstrating the potential of [CMF] to enhance outcomes.

Multimodal Treatment for Breast Cancer: A Multi-Pronged Approach

The study's findings suggest that [CMF] can be a valuable tool in [breast cancer] management, particularly when combined with [surgical intervention]. The improved survival rates observed in the [CMF group] highlight the potential of [chemotherapy] to enhance treatment efficacy. Further research is needed to explore the long-term effects of [CMF] and to refine optimal treatment strategies for different stages and subtypes of [breast cancer].

Multimodal Treatment for Breast Cancer: A Multi-Pronged Approach

The battle against [breast cancer] requires a comprehensive and collaborative approach, combining [surgical intervention, chemotherapy, and other treatment modalities] to maximize patient outcomes. This study provides a valuable insight into the benefits of a multimodality approach, emphasizing the importance of seeking expert medical guidance and tailored treatment plans.

Dr. Camel's Conclusion

This research, like a caravan traversing a vast desert, underscores the importance of a multimodality approach in [breast cancer] treatment. The findings highlight the potential of [CMF] to improve outcomes, but the journey towards optimal care requires ongoing research and collaboration. Just as a camel relies on its strength and resilience to navigate the desert, patients facing [breast cancer] need access to the best possible treatment options and unwavering support throughout their journey.

Date :
  1. Date Completed 1981-07-20
  2. Date Revised 2019-05-01
Further Info :

Pubmed ID

6784849

DOI: Digital Object Identifier

10.1136/bmj.282.6274.1427

Related Literature

Article Analysis
・Effective treatment of breast cancer
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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