Pimozide in the treatment of newly admitted schizophrenic patients.

Author: AnnableL, ChouinardG

Paper Details 
Original Abstract of the Article :
Pimozide, a specific dopamine blocking agent, was compared with chlorpromazine in a 4-week double-blind study of the treatment of 40 schizophrenic patients newly admitted to hospital through the emergency room. Dosage was adjusted according to therapeutic effect and during the final week ranged from...See full text at original site
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元:
https://doi.org/10.1007/BF00430747

データ提供:米国国立医学図書館(NLM)

Pimozide vs. Chlorpromazine: A Tale of Two Antipsychotics

The field of [schizophrenia] treatment continues to evolve, with researchers constantly seeking new and effective medications. This study compares the effectiveness of two antipsychotics, [pimozide] and [chlorpromazine], in treating newly admitted schizophrenic patients. The study employed a [double-blind] design to assess the therapeutic effects of both drugs over a four-week period.

Pimozide's Role in Schizophrenia Treatment: A Less Potent Approach

The study found that pimozide exhibited a slightly less potent therapeutic effect compared to chlorpromazine, particularly in patients presenting with high levels of agitation. While pimozide induced more parkinsonian symptoms, it resulted in fewer autonomic side effects. Interestingly, the study observed a better response to both treatments in women compared to men.

Navigating the Side Effects: Balancing Benefits and Risks

The findings highlight the importance of carefully considering the potential side effects associated with antipsychotic medications. While pimozide may be less potent than chlorpromazine, it offers a different side effect profile. Ultimately, the choice of treatment depends on the individual patient's needs and preferences, taking into account both the therapeutic benefits and the potential risks.

Dr.Camel's Conclusion

Just like a camel choosing its path through a desert, we must carefully consider the options when it comes to treating schizophrenia. This study provides valuable insights into the effectiveness and side effects of pimozide and chlorpromazine, helping us make informed decisions for our patients. Ultimately, the goal is to find the treatment that best suits the individual's needs, ensuring a balanced approach to managing this complex condition.

Date :
  1. Date Completed 1982-07-19
  2. Date Revised 2019-07-26
Further Info :

Pubmed ID

6805002

DOI: Digital Object Identifier

10.1007/BF00430747

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Languages

English

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