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Lithium attenuates dopamine depleting effects of reserpine and tetrabenazine but not that of alpha methyl-p-tyrosine.

Author: FahnS, HassanM N, JacksonV R, RechesA

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Lithium attenuated the dopamine-depleting effects of reserpine and tetrabenazine in rat brains. This interaction may affect the efficacy of these drugs in patients with tardive dyskinesia or dystonia.
Paper Details　
Original Abstract of the Article :
Concurrent administration of lithium (Li) significantly attenuates the dopamine (DA) depleting effects of reserpine and tetrabenazine, but does not change alpha-methyl-p-tyrosine (AMPT) induced DA depletion in rat brain. This effect of Li is probably mediated, in part, by inhibiting the magnesium-de...See full text at original site
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引用元：
https://doi.org/10.1016/0024-3205(83)90408-3

データ提供：米国国立医学図書館（NLM）

Lithium: A Potential Modifier of Dopamine Depletion

Dopamine, a neurotransmitter responsible for regulating mood, movement, and reward, can be affected by certain medications. This research investigates the potential interaction between lithium, a medication used to treat bipolar disorder, and other drugs that influence dopamine levels.

Lithium's Impact on Dopamine Depletion

The study found that lithium significantly attenuated the dopamine-depleting effects of reserpine and tetrabenazine, two drugs known to reduce dopamine levels. This finding suggests that lithium may have a protective effect on dopamine levels, potentially mitigating the side effects of these medications.

Navigating Drug Interactions

This research highlights the importance of considering potential drug interactions when prescribing medications that affect dopamine levels. By understanding the complex interplay between these drugs, healthcare providers can make informed decisions to optimize treatment outcomes and minimize potential side effects.

Dr.Camel's Conclusion

This research explores the intricate interplay between lithium and other drugs that influence dopamine levels. The study's findings suggest that lithium may have a protective effect on dopamine, offering valuable insights for optimizing treatment strategies and minimizing potential drug interactions.

Date :
  1. Date Completed 1983-08-17
  2. Date Revised 2019-07-01
Further Info :

Pubmed ID

6865653

DOI: Digital Object Identifier

10.1016/0024-3205(83)90408-3

Related Literature

Article Analysis
・Effects of tetrabenazine
SNS
PICO Info
in preparation
Languages

English

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