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Dose-related interaction between timolol and adrenaline.

Author: OhrströmA

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Oral timolol and adrenaline eye drops had an additive effect on IOP when timolol was given in a lower dose. The effect was antagonistic with a higher dose of timolol.
Paper Details　
Original Abstract of the Article :
The effects on IOP of a combination of oral timolol maleate and adrenaline eye drops were investigated in a double-blind randomized trial using health volunteers. Timolol was given in two doses, 20 and 5 mg a day. One percent adrenaline eye drops were given to one eye, placebo to the other. The resu...See full text at original site
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引用元：
https://doi.org/10.1007/BF00407777

データ提供：米国国立医学図書館（NLM）

Timolol and Adrenaline: A Complex Interaction in IOP Management

Glaucoma, a condition characterized by damage to the optic nerve, is a leading cause of blindness. This research investigates the interaction between timolol maleate, a beta-blocker commonly used to lower intraocular pressure (IOP), and adrenaline eye drops, another IOP-lowering agent.

Unveiling the Complexity: Additive and Antagonistic Effects

The study found that the effect of adrenaline on IOP was influenced by the dose of timolol. With a lower dose of timolol, adrenaline had an additive effect, meaning it further lowered IOP. However, with a higher dose of timolol, adrenaline exhibited an antagonistic effect, counteracting the IOP-lowering effects of timolol. This research highlights the complex interactions between these two IOP-lowering agents.

Optimizing Treatment: Tailoring Therapy for Individual Needs

Imagine a world where glaucoma patients can receive tailored treatments that maximize the benefits and minimize the risks of IOP-lowering medications. This research underscores the importance of individualizing treatment plans to account for potential drug interactions. By carefully considering these factors, healthcare providers can optimize treatment strategies and improve the lives of glaucoma patients.

Dr. Camel's Conclusion

This research provides a valuable insight into the intricate interplay between timolol and adrenaline in IOP management. The study's findings suggest that the dose of timolol can significantly influence the effect of adrenaline on IOP. This underscores the need for careful monitoring and dose adjustments to ensure optimal treatment outcomes. By navigating the complexities of drug interactions, we can strive to provide the best possible care for glaucoma patients.

Date :
  1. Date Completed 1981-07-23
  2. Date Revised 2020-03-04
Further Info :

Pubmed ID

6909025

DOI: Digital Object Identifier

10.1007/BF00407777

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SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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