Effects of diflunisal on platelet function and fecal blood loss.

Author: DaviesR O, GreenD, HolmesG I, KohlH, LeeR B, ReynoldsN, SchmidF R, Ts'aoC

Paper Details 
Original Abstract of the Article :
The effects of diflunisal, a nonacetylated difluorinated salicylate, on platelet function were compared with those of aspirin and placebo. In a randomized, double-blind trial, normal subjects were given diflunisal, 250, 500, or 1,000 mg twice daily; aspirin, 650 or 1,300 mg twice daily; or placebo f...See full text at original site
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引用元:
https://doi.org/10.1038/clpt.1981.176

データ提供:米国国立医学図書館(NLM)

Diflunisal: Impact on Platelet Function and Fecal Blood Loss

This study delves into the world of platelet function, investigating the effects of diflunisal, a non-acetylated difluorinated salicylate, on platelet aggregation and gastrointestinal bleeding. It's like exploring the intricate workings of a desert ecosystem, understanding how different elements interact and influence one another.

Diflunisal: Less Impact on Platelet Function

The study found that diflunisal, in doses comparable to aspirin, exhibited less inhibition of platelet function, suggesting potential advantages for patients at risk for bleeding. It's like discovering a plant with a similar therapeutic effect as another but with a less disruptive impact on a specific aspect of the desert ecosystem.

Managing Gastrointestinal Side Effects

The study also revealed that diflunisal, while less impactful on platelets, still had the potential to increase fecal blood loss. It's like recognizing that even beneficial plants can have unintended consequences, requiring careful monitoring and management to minimize negative impacts.

Dr.Camel's Conclusion

This research, like a meticulous study of the desert's diverse flora, provides valuable insights into the effects of diflunisal on platelet function and gastrointestinal bleeding. It highlights the need for a balanced approach, considering both the potential benefits and risks of this medication and carefully weighing its use for specific patients.

Date :
  1. Date Completed 1981-11-18
  2. Date Revised 2019-05-11
Further Info :

Pubmed ID

6974077

DOI: Digital Object Identifier

10.1038/clpt.1981.176

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English

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