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Effects of diflunisal on platelet function and fecal blood loss.
Author: DaviesR O, GreenD, HolmesG I, KohlH, LeeR B, ReynoldsN, SchmidF R, Ts'aoC
Original Abstract of the Article :
The effects of diflunisal, a nonacetylated difluorinated salicylate, on platelet function were compared with those of aspirin and placebo. In a randomized, double-blind trial, normal subjects were given diflunisal, 250, 500, or 1,000 mg twice daily; aspirin, 650 or 1,300 mg twice daily; or placebo f...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1038/clpt.1981.176
データ提供:米国国立医学図書館(NLM)
Diflunisal: Impact on Platelet Function and Fecal Blood Loss
This study delves into the world of platelet function, investigating the effects of diflunisal, a non-acetylated difluorinated salicylate, on platelet aggregation and gastrointestinal bleeding. It's like exploring the intricate workings of a desert ecosystem, understanding how different elements interact and influence one another.
Diflunisal: Less Impact on Platelet Function
The study found that diflunisal, in doses comparable to aspirin, exhibited less inhibition of platelet function, suggesting potential advantages for patients at risk for bleeding. It's like discovering a plant with a similar therapeutic effect as another but with a less disruptive impact on a specific aspect of the desert ecosystem.
Managing Gastrointestinal Side Effects
The study also revealed that diflunisal, while less impactful on platelets, still had the potential to increase fecal blood loss. It's like recognizing that even beneficial plants can have unintended consequences, requiring careful monitoring and management to minimize negative impacts.
Dr.Camel's Conclusion
This research, like a meticulous study of the desert's diverse flora, provides valuable insights into the effects of diflunisal on platelet function and gastrointestinal bleeding. It highlights the need for a balanced approach, considering both the potential benefits and risks of this medication and carefully weighing its use for specific patients.
Date :
- Date Completed 1981-11-18
- Date Revised 2019-05-11
Further Info :
Related Literature
English
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