Effects of diflunisal: A Synthesis of Findings from 22 Studies

  1. Home
  2. Effects of diflunisal
This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Effects of diflunisal: A Synthesis of Findings from 22 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Effects of diflunisal: A Synthesis of Findings from 22 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to DatasetPlease check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Main Research Findings

Diflunisal is a nonsteroidal anti-inflammatory drug (NSAID) that has been shown to be effective in reducing pain, especially in patients with osteoarthritis. 7 found that diflunisal was similarly effective as ibuprofen in treating osteoarthritis, with both drugs improving pain, joint mobility, functional capacity, and joint swelling and tenderness. 3 showed that diflunisal was more effective than paracetamol in reducing postoperative pain following impacted mandibular third molar surgery. 4 found similar results, demonstrating that diflunisal provided greater pain relief, swelling reduction, and improved mouth opening compared to paracetamol after impacted wisdom tooth extraction. Additionally, research suggests that diflunisal might be a safer choice for patients with kidney or liver problems, as it does not significantly impact renal function in these individuals. 8 observed that diflunisal did not worsen renal function in patients with cirrhosis and ascites. 9 confirmed that diflunisal did not have a negative impact on renal function in healthy individuals. 17 indicated that diflunisal was effective in reducing pain and swelling in patients with chronic polyarthritis.

Furthermore, studies have investigated the effects of diflunisal on platelet function and compared its effects to aspirin. 18 revealed that diflunisal, in doses similar to aspirin, showed less inhibition of platelet function, indicating a lower risk of bleeding complications. 19 found similar results, demonstrating that diflunisal inhibited platelet function to a lesser extent than aspirin in the same dose range.

Benefits and Risks

Benefits Summary

Diflunisal can be an effective pain reliever for conditions like osteoarthritis and postoperative pain. It is also a possible safer alternative for patients with pre-existing kidney or liver issues. Diflunisal may have a lower risk of bleeding complications compared to aspirin.

Risks Summary

Diflunisal can cause gastrointestinal side effects like stomach pain, nausea, and digestive discomfort. 7 suggests that diflunisal may cause minor changes in gastric mucosa, though it is well-tolerated. 14 showed that diflunisal may be gentler on the stomach compared to naproxen. However, 1 highlighted that diflunisal might increase cellular iron levels and induce oxidative stress. Additionally, diflunisal can affect blood clotting and may increase bleeding time. 12 observed that diflunisal might prolong bleeding time in oral surgery patients. It is crucial to consult a doctor before taking diflunisal, especially if you have pre-existing gastrointestinal issues, bleeding disorders, or are taking other medications.

Comparison of Studies

Similarities of Studies

Most studies consistently suggest that diflunisal is an effective pain reliever, particularly for osteoarthritis and postoperative pain. Research generally shows that diflunisal has a lower risk of affecting platelet function and causing bleeding compared to aspirin.

Differences in Studies

While research indicates that diflunisal is effective in reducing pain, there are discrepancies in its impact on the gastrointestinal system. Some studies, like 7 , suggest minor changes in gastric mucosa, while others, like 14 , show that it might be less harsh on the stomach compared to other NSAIDs. Additionally, studies have explored the impact of combining diflunisal with other medications. 20 suggests that diflunisal combined with nifedipine may decrease uterine activity, while 22 indicates that combining diflunisal with indomethacin might reduce the adverse effects on the gastric mucosa. These findings highlight the potential for drug interactions to influence the effects and side effects of diflunisal.

Consistency and Contradictions in Findings

While research consistently points towards diflunisal's effectiveness in reducing pain, there is some inconsistency in its impact on the gastrointestinal system. These discrepancies might be due to variations in research methodology, study populations, and the specific drug combinations used. Further research is needed to better understand the long-term effects of diflunisal on the stomach.

Real-World Application and Precautions

Diflunisal can be a helpful pain reliever for various conditions, but it is essential to be aware of its potential side effects. Consult a doctor before taking diflunisal, especially if you have pre-existing stomach ulcers, bleeding disorders, or are taking other medications. It is important to weigh the potential benefits and risks of diflunisal based on your individual health status and medical history.

Limitations of Current Research

Further research is needed to fully understand the long-term effects of diflunisal, particularly its impact on the gastrointestinal system. More studies are also necessary to investigate the interactions between diflunisal and other medications. This information is crucial to ensure the safe and effective use of diflunisal for various patient populations.

Future Research Directions

Future research should focus on investigating the long-term impact of diflunisal on the stomach, particularly in high-risk individuals. Additionally, research should explore the interaction of diflunisal with other medications to ensure safe and effective treatment strategies for various patient populations.

Conclusion

Diflunisal is a promising pain reliever, particularly for osteoarthritis, and may have a lower risk of bleeding complications compared to aspirin. However, it is important to be aware of its potential gastrointestinal side effects and consult with a doctor before taking it. Further research is necessary to better understand the long-term effects and interactions of diflunisal. It's vital to discuss your individual health needs and medical history with a healthcare professional to determine if diflunisal is an appropriate treatment option for you.

Literature analysis of 22 papers
Positive Content
16
Neutral Content
2
Negative Content
4
Article Type
7
0
0
0
22
1.

A new ferrous diflunisal complex and its effects on biopools of labile iron.

Author: SihnLuca Michael, de MeloFernando Menegatti, TomaHenrique Eisi, SerranoSilvia Helena Pires, EspósitoBreno Pannia

Oxidative stress

This study investigated the ability of diflunisal to alter labile pools of iron in both plasma and cells. While diflunisal did not increase redox-active iron in plasma, it efficiently carried iron into cells, leading to iron-catalyzed oxidative stress.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

2.

Modifications of diflunisal and meclofenamate carboxyl groups affect their allosteric effects on GABAA receptor ligand binding.

Author: Uusi-OukariMikko, VähätaloLaura, LiljebladArto

GABAAR modulation

Modifying the carboxyl group of diflunisal and meclofenamate can affect their ability to modulate GABAARs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Clinical effects of diflunisal and paracetamol in impacted mandibular third molar surgery.

Author: SençiftK, KirS, TuncerM

Pain relief
Swelling reduction
Trismus relief

Diflunisal was more effective than paracetamol in reducing postoperative pain, swelling, and trismus after impacted mandibular third molar surgery.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

Comparison of the analgesic effects of diflunisal and paracetamol in the treatment of postoperative dental pain.

Author: SelçukE, GomelM, BellibasS E, KöseT, TuğlularI

Pain relief

This study found that diflunisal was significantly more effective than paracetamol in relieving pain caused by the surgical removal of impacted mandibular third molars.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Effects of blockage of urine and/or bile flow on diflunisal conjugation and disposition in rats.

Author: WattJ A, DickinsonR G

Accumulation of conjugates

Diflunisal, a nonsteroidal anti-inflammatory drug, was found to be primarily eliminated in bile as conjugates. Blockage of either the urinary or biliary excretion routes significantly impacted the elimination of diflunisal and its conjugates.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Sex-difference and the effects of smoking and oral contraceptive steroids on the kinetics of diflunisal.

Author: MacdonaldJ I, HermanR J, VerbeeckR K

Increased clearance in smokers

Diflunisal clearance was significantly higher in men and women on oral contraceptives compared to control women. Smoking also increased diflunisal clearance, but reduced total urinary recovery.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

Diflunisal and ibuprofen: effects on gastric and duodenal mucosa in patients with osteoarthritis.

Author: MuncieH L, NasrallahS M

joint mobility improvement
osteoarthritis pain reduction
gastrointestinal side effects

Diflunisal and ibuprofen were equally effective in treating osteoarthritis patients with similar tolerability. Both drugs showed some gastrointestinal side effects, even during short-term use, but these were not always correlated with symptoms.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Comparative acute effects of diflunisal and indomethacin on renal function in patients with cirrhosis and ascites.

Author: AntillonM, CominelliF, ReynoldsT B, ZipserR D

Renal function preservation
Renal impairment

Diflunisal was less likely to affect renal function than indomethacin in patients with cirrhosis and ascites.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Comparative acute effects of aspirin, diflunisal, ibuprofen and indomethacin on renal function in healthy man.

Author: BergamoR R, CominelliF, KoppleJ D, ZipserR D

Minimized effects on platelet and kidney function
Reduced diuretic response
Reduced renal perfusion
Renal impairment

Indomethacin has significant adverse effects on renal function, while nonacetylated salicylates, such as diflunisal, may have less deleterious effects.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

Effects of diflunisal on cutaneous sensory and pain thresholds.

Author: DraganiL, GiamberardinoM A, ObletterG, VecchietL

Pain relief
Side effects

Diflunisal, an analgesic, increased pain threshold in healthy human subjects. The effect was dose-related, with a greater increase in pain threshold after 1 gm than after 500 mg of diflunisal.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

13.

Comparison of the urate lowering effects of allopurinol and diflunisal.

Author: EmmersonB T, HazeltonR A, WhyteI M

Antiinflammatory effect
Lower urate levels

Diflunisal, a drug with anti-inflammatory and uricosuric (uric acid-lowering) effects, was compared to allopurinol for gout treatment. Diflunisal increased serum urate levels, but still kept them within the optimal range for most patients. This suggests diflunisal may be beneficial for patients requiring both anti-inflammatory and uricosuric effects.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

A single blind randomized endoscopic study comparing the effects of diflunisal and naproxen in patients with osteoarthritis.

Author: GarberE K, GuthP H, SilpaM L, StolzA

Less gastric injury

Diflunisal caused significantly less gastric injury than naproxen in 34 patients with osteoarthritis. 65% of patients treated with diflunisal had no evidence of gastric mucosal injury compared to 13% in the naproxen group.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

15.

Dose-dependent pharmacokinetics of diflunisal in rats: dual effects of protein binding and metabolism.

Author: LinJ H, HookeK F, YehK C, DugganD E

Saturable metabolism and protein binding were found to affect the pharmacokinetics of diflunisal in rats. Both processes contributed to a decrease in total body plasma clearance at higher concentrations.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

16.

Effects of diflunisal on fever in the rabbit and the rat.

Author: DascombeM J

Antipyretic effect
Hyperthermia

Diflunisal is a more potent antipyretic than aspirin in rats. However, its toxicity is potentiated by the presence of pyrogens.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

17.

[Comparison of the effects of diflunisal, ibuprofen and placebo in chronic polyarthritis].

Author: FaschingU

Significant improvement
Adverse reactions

Diflunisal was effective in treating rheumatoid arthritis and was comparable to ibuprofen in efficacy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

18.

Effects of Diflunisal on Platelet Function and Fecal Blood Loss.

Author: GreenDavid, DaviesRichard O, HolmesGeoffrey I, KohlHelga, LeeRobyn B, ReynoldsNancy, SchmidFrank R, Ts'aoChung-Hsin

Inhibit platelet function less
Increased fecal blood loss

The effects of diflunisal, aspirin, and placebo on platelet function were compared in a randomized, double-blind trial. Diflunisal showed less inhibition of platelet function than aspirin, with its effects returning to baseline within 24 hours of discontinuation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

19.

Effects of diflunisal on platelet function and fecal blood loss.

Author: GreenD, DaviesR O, HolmesG I, KohlH, LeeR B, ReynoldsN, SchmidF R, Ts'aoC H

Increased fecal blood loss
Inhibited platelet function

Diflunisal, a nonacetylated salicylate, inhibited platelet function less than aspirin at similar doses. Diflunisal at 250 mg had no effect, 500 mg had minimal inhibition, and 1000 mg had moderate inhibition. Aspirin at 650 mg had significant inhibition, and 1300 mg had a longer duration of action.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

21.

Effects of diflunisal on platelet function and fecal blood loss.

Author: GreenD, DaviesR O, HolmesG I, KohlH, LeeR B, ReynoldsN, SchmidF R, Ts'aoC

Inhibition of platelet function

Diflunisal inhibits platelet function less than aspirin in the same dosage range.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.