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Effect of guanabenz and hydrochlorothiazide on blood pressure and plasma renin activity.

Author: FairchildC, Gomez-SanchezC E, HollandO B

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Guanabenz, a new antihypertensive drug, was found to be more effective when used with a diuretic.
Paper Details　
Original Abstract of the Article :
Patients with mild to moderate essential hypertension were treated with guanabenz plus placebo (26 patients) or guanabenz plus hydrochlorothiazide (26 patients) for one year. Ambulatory plasma renin activity was determined during placebo treatment, after four weeks and one year of treatment with the...See full text at original site
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引用元：
https://doi.org/10.1002/j.1552-4604.1981.tb05690.x

データ提供：米国国立医学図書館（NLM）

Guanabenz and Hydrochlorothiazide: A Synergistic Approach to Hypertension

This research explores the effectiveness of guanabenz, a new antihypertensive medication, in treating mild to moderate essential hypertension. The researchers conducted a one-year study comparing the effects of guanabenz alone and in combination with hydrochlorothiazide, a diuretic commonly used for hypertension. They found that guanabenz plus hydrochlorothiazide was more effective than guanabenz alone in controlling blood pressure, leading to fewer treatment failures and better long-term control.

Synergistic Effects of Guanabenz and Hydrochlorothiazide

The study revealed that combining guanabenz with hydrochlorothiazide resulted in a synergistic effect, enhancing blood pressure control and reducing the need for higher doses of guanabenz. This finding suggests that combining medications can be an effective strategy for managing hypertension.

Managing Hypertension: A Team Effort

This research underscores the importance of a multi-pronged approach to managing hypertension. It highlights the potential benefits of combining different medications to achieve optimal blood pressure control.

Dr. Camel's Conclusion

This study demonstrates the effectiveness of guanabenz in combination with hydrochlorothiazide for treating hypertension. The researchers' findings highlight the importance of considering medication combinations in managing chronic conditions and the potential for synergistic effects to improve patient outcomes.

Date :
  1. Date Completed 1981-08-10
  2. Date Revised 2019-08-25
Further Info :

Pubmed ID

7016928

DOI: Digital Object Identifier

10.1002/j.1552-4604.1981.tb05690.x

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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