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A controlled comparison of trimipramine and amitriptyline.

Author: KlineN S

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Both trimipramine and amitriptyline effectively treated depression in 41 patients. Amitriptyline showed greater improvement in global rating, but trimipramine patients were more seriously ill and showed significant improvement in week 2 with fewer side effects.
Paper Details　
Original Abstract of the Article :
Depressed patients seen in a private psychiatric practice (N = 41) were randomly assigned to receive trimipramine or amitriptyline over a study period of at least 4 weeks. Patients in both groups showed significant improvement over time on measures of mood and depression, and on psychological scales...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/7037756

データ提供：米国国立医学図書館（NLM）

Comparing Trimipramine and Amitriptyline: A Head-to-Head Analysis

Depression is a prevalent mental health condition, and finding effective treatments is a priority. This study compares the effectiveness of two antidepressants, trimipramine and amitriptyline, in treating depressed patients. The researchers aimed to determine whether one drug offered a more significant advantage over the other in terms of efficacy and side effects.

Trimipramine Shows Promise for Early Response in Depression

While both drugs demonstrated improvement in mood and depression symptoms, the study found that trimipramine might be particularly beneficial for patients who are sensitive to side effects and require evidence of early response. Trimipramine patients showed a more significant improvement at week 2 compared to amitriptyline patients, suggesting a quicker onset of therapeutic effects.

Navigating Depression Treatment: Finding the Right Fit

Finding the right antidepressant can be a journey of trial and error. This study provides valuable insights into the potential benefits of trimipramine, particularly for patients who prioritize a quick response and minimal side effects. Think of it like this: a camel traversing a desert might choose a path based on the terrain and its own capabilities. Similarly, a person seeking treatment for depression needs to find the right medication and therapeutic approach to fit their needs.

Dr. Camel's Conclusion

This research offers valuable insights into the comparative effectiveness of trimipramine and amitriptyline in treating depression. The findings suggest that trimipramine might be a suitable option for certain patients, particularly those seeking a quick response and minimal side effects. Remember, every individual's journey with depression is unique, and finding the right treatment is a crucial step in managing this complex condition.
Date :
  1. Date Completed 1982-05-21
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

7037756

DOI: Digital Object Identifier

7037756

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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