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[Simultaneous or sequential hormono/chemotherapy and a comparison of various polychemotherapies in the treatment of metastatic breast cancer].

Author: AlbertoP, BeerM, BrunnerK W, CavalliF, JungiW F, MartzG, MermillodB, ObrechtJ P

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

A study of 396 patients with advanced breast cancer compared combined chemo/hormonotherapy to hormonotherapy alone, followed by chemotherapy when tumor progression occurred. Premenopausal patients tended to live longer with the combined approach, while postmenopausal patients fared better with delayed chemotherapy. The difference in survival was statistically significant only in postmenopausal patients with less aggressive tumors. More intensive chemotherapy resulted in higher response rates, but only marginally improved survival. These findings suggest that the optimal treatment strategy for advanced breast cancer may vary depending on patient characteristics and tumor aggressiveness.
Paper Details　
Original Abstract of the Article :
Since in the treatment of advanced breast cancer chemotherapy and the various hormonal manipulations seem recently to have reached a plateau of effectiveness when used alone, it is widely assumed that the combination of both treatment modalities could improve therapeutic results. The outcome is repo...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/7048518

データ提供：米国国立医学図書館（NLM）

Metastatic Breast Cancer: A Complex Desert Landscape

Metastatic breast cancer, a formidable adversary, presents a unique challenge to oncologists. This study explores the effectiveness of combining chemotherapy and hormonal therapy in treating metastatic breast cancer. It's like charting a complex desert landscape, seeking the most effective routes to combat this challenging disease.

A Two-Pronged Approach: Combining Chemotherapy and Hormonal Therapy

The study investigates the impact of concurrent vs. sequential chemo/hormonotherapy on the survival of patients with metastatic breast cancer. This approach, like using a combination of camels and off-road vehicles to traverse the desert, aims to maximize treatment efficacy by targeting different aspects of the disease.

Navigating the Desert of Metastatic Breast Cancer: A Search for Effective Therapies

The study findings highlight the importance of personalized treatment approaches, suggesting that the optimal strategy may vary depending on the patient's characteristics and the nature of the disease. It's like recognizing that different desert landscapes require different modes of transportation and survival strategies.

Dr.Camel's Conclusion

This research emphasizes the need for ongoing exploration and refinement of treatment strategies for metastatic breast cancer. It's like continuously mapping and navigating a vast and ever-changing desert landscape, seeking new and innovative pathways to combat this challenging disease.

Date :
  1. Date Completed 1982-09-17
  2. Date Revised 2015-11-19
Further Info :

Pubmed ID

7048518

DOI: Digital Object Identifier

7048518

Related Literature

Article Analysis
・Effective treatment of breast cancer
SNS
PICO Info
in preparation
Languages

German

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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