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Pharmacokinetics of cefaclor in renal failure: effects of multiple doses and hemodialysis.

Author: BoltonW K, GoberL L, SandeM A, ScheldW M, SpykerD A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Cefaclor, a cephalosporin antibiotic, was found to be safe and effective in treating functionally anephric patients on hemodialysis. In a study involving 15 patients, cefaclor was cleared with an average half-life of 2.9 hours without hemodialysis and 1.5 hours during hemodialysis.
Paper Details　
Original Abstract of the Article :
The pharmacokinetics of cefaclor were characterized in 15 functionally anephric patients on hemodialysis. Each patient received a 500-mg oral dose of cefaclor every 8 h for 10 days. Multiple serum drug levels were measured by bioassay on day 0 (no hemodialysis), day 10 during hemodialysis, and as si...See full text at original site
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引用元：
https://doi.org/10.1128/AAC.21.2.278

データ提供：米国国立医学図書館（NLM）

Cefaclor in Renal Failure: Navigating the Desert of Kidney Disease

Cefaclor, an antibiotic, is often prescribed for bacterial infections. This study examines the pharmacokinetics of cefaclor in patients with renal failure, investigating how the drug is processed and eliminated by the body when kidney function is impaired. Imagine cefaclor as a desert caravan navigating a treacherous terrain, needing careful guidance to reach its destination. Researchers studied the drug's behavior in patients undergoing hemodialysis, analyzing blood levels of cefaclor over time to understand its absorption, distribution, metabolism, and excretion.

Cefaclor in the Desert of Kidney Failure

The study found that cefaclor's half-life, the time it takes for the drug to be eliminated from the body, was significantly shorter in patients undergoing hemodialysis. This suggests that patients with renal failure may require adjustments in their medication dosage or frequency to ensure effective treatment while minimizing potential side effects.

Managing Medications in Renal Failure

It's crucial for patients with renal failure to discuss medication adjustments with their healthcare providers to ensure safe and effective treatment.

Dr.Camel's Conclusion

Cefaclor, like a seasoned desert caravan leader, requires careful navigation in the arid landscape of kidney disease. This study provides valuable insights into the pharmacokinetic behavior of cefaclor in patients with renal failure, guiding healthcare providers in optimizing drug therapy for this challenging population.

Date :
  1. Date Completed 1982-06-24
  2. Date Revised 2021-05-26
Further Info :

Pubmed ID

7073265

DOI: Digital Object Identifier

10.1128/AAC.21.2.278

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in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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