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"Low dose" colestipol in children, adolescents and young adults with familial hypercholesterolemia.

Author: HeuckC C, MiddelhoffG, MrozikK, OsterP, RiesenW, SchellenbergB, SchlierfG

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Colestipol, a bile acid sequestrant, was found to be effective in lowering plasma cholesterol levels in children, adolescents, and young adults with familial hypercholesterolemia. In a study involving 11 patients, colestipol significantly reduced total cholesterol and LDL cholesterol, while increasing HDL cholesterol.
Paper Details　
Original Abstract of the Article :
The effect of colestipol on plasma lipids and lipoproteins was studied in children, adolescents and young adults with familial hypercholesterolemia. O.125 g or 0.25 g/kg body weight were given in randomized sequence for period of 4 weeks. Total cholesterol was lowered by 13 and 18% with the smaller ...See full text at original site
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引用元：
https://doi.org/10.1016/0021-9150(82)90077-6

データ提供：米国国立医学図書館（NLM）

Lowering Cholesterol in Youngsters: A Study on Colestipol

Navigating the vast desert of lipid disorders, we encounter a study focusing on the efficacy of colestipol in treating familial hypercholesterolemia in children, adolescents, and young adults. This research delves into the effects of colestipol on plasma lipids and lipoproteins by employing a randomized controlled trial. The researchers discovered that colestipol, when administered in low doses, effectively reduced total cholesterol levels by 13% and 18% for the smaller and larger doses, respectively. LDL cholesterol levels were also lowered by 15% and 12% with the smaller and larger doses, respectively. Interestingly, HDL cholesterol levels saw an increase of 18% and 32%. This indicates that colestipol may have potential benefits in managing high cholesterol levels in younger individuals.

The Promise of Low-Dose Colestipol

This study suggests that low-dose colestipol, despite being less effective in lowering total plasma and LDL cholesterol compared to conventional doses, holds promise for treating familial hypercholesterolemia in young individuals. The researchers highlight the minimal side effects associated with low-dose colestipol, making it a potentially advantageous option for children, adolescents, and young adults whose cholesterol levels remain elevated after dietary interventions.

Navigating the Desert of Cholesterol

Managing cholesterol levels is like navigating a vast desert. Just as one needs to carefully plan their journey and choose the right supplies, managing cholesterol requires a personalized approach. This research sheds light on the potential benefits of low-dose colestipol, a tool in our arsenal for combating high cholesterol. However, just as a traveler must be aware of the dangers of the desert, it's crucial to consult with a healthcare professional to determine the right treatment strategy for your specific needs.

Dr.Camel's Conclusion

This research provides valuable insights into the potential benefits of low-dose colestipol for managing cholesterol in young individuals. While it may not be the most effective solution for all cases, its minimal side effects and potential to improve lipid profiles make it a promising tool for treating familial hypercholesterolemia in younger patients.

Date :
  1. Date Completed 1982-06-14
  2. Date Revised 2019-07-18
Further Info :

Pubmed ID

7073790

DOI: Digital Object Identifier

10.1016/0021-9150(82)90077-6

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SNS
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in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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