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Effect of cimetidine and antacid on gastric microbial flora.

Author: KayeD, KobasaW D, PoporadG A, RomanoJ M, SneparR

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Cimetidine, a drug used to treat ulcers, was found to increase microbial titers in the stomach, particularly mouth flora, compared to antacids. However, there was no significant difference in the overall microbial composition or titers between the two groups.
Paper Details　
Original Abstract of the Article :
The effect of a standard regimen of cimetidine on the gastric flora of 20 male volunteers was studied in a double-blind manner and compared with the effects of a standard antacid regimen. Postprandial microbial titers in gastric aspirates were significantly higher at 4, 8, and 16 weeks of therapy in...See full text at original site
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引用元：
https://doi.org/10.1128/iai.36.2.518-524.1982

データ提供：米国国立医学図書館（NLM）

Investigating the Effects of Cimetidine and Antacid on Gastric Flora

This research explores the impact of two commonly used medications, cimetidine (an H2-receptor antagonist) and antacids, on the microbial flora of the stomach. The study investigates the effects of these medications on the composition and abundance of bacteria in the stomach. Researchers aimed to determine whether these medications altered the balance of bacteria in the stomach and, if so, whether this had any clinical implications.

A Closer Look at Gastric Flora

This research offers a glimpse into the intricate ecosystem of the stomach, revealing the complex interplay between medications and the microbial inhabitants. It's like exploring a hidden world beneath the surface of the desert sands, discovering the secrets of a vibrant and diverse microcosm.

Navigating the Complexities of Gastric Health

This research underscores the importance of considering the potential impact of medications on the delicate balance of the gut microbiome. Just as a camel caravan needs to be mindful of its surroundings and adapt its course accordingly, so too must healthcare providers be aware of the potential side effects of medications on the gut.

Dr. Camel's Conclusion

This research provides valuable insights into the effects of commonly used medications on the gastric flora. It emphasizes the need to carefully consider the potential impact of these medications on the gut microbiome and to explore alternative strategies for managing gastric conditions. Just as a camel caravan navigates the vast and unpredictable desert, so too must we navigate the complex world of gut health with caution and a keen understanding of the delicate balance within.
Date :
  1. Date Completed 1982-08-26
  2. Date Revised 2021-05-26
Further Info :

Pubmed ID

7085070

DOI: Digital Object Identifier

10.1128/iai.36.2.518-524.1982

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・Effects of cimetidine
SNS
PICO Info
in preparation
Languages

English

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