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Effects of placebo versus guanabenz on hypertensive out-patients.

Author: GoldJ A, RudnickM R, SchneiderB E, WalkerB R

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Guanabenz acetate was effective in treating hypertension in outpatients. 70% of guanabenz-treated patients experienced a clinically significant decrease in blood pressure, compared with 41% of placebo-treated patients. The most common side effects were sedation and dry mouth.
Paper Details　
Original Abstract of the Article :
The objectives of this study were two-fold: (1) 1 4-week multicentre, randomized, double-blind efficacy comparison of placebo and guanabenz acetate, a new centrally acting antihypertensive drug, in 168 hypertensive out-patients and (2) a more accurate determination of the incidence of drug-related, ...See full text at original site
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引用元：
https://doi.org/10.1177/030006058000800501

データ提供：米国国立医学図書館（NLM）

Guanabenz: A New Approach to High Blood Pressure

This study ventures into the field of hypertension, exploring the efficacy of a new centrally acting antihypertensive drug, guanabenz acetate, in treating high blood pressure. The researchers conducted a randomized, double-blind trial comparing guanabenz with a placebo, evaluating its impact on blood pressure and side effects in a diverse group of hypertensive outpatients. Their goal was to understand the effectiveness of guanabenz and to determine the frequency of potential side effects.

Guanabenz's Effectiveness in Lowering Blood Pressure

The results showed that guanabenz effectively reduced blood pressure compared to the placebo group, with a significant decrease in supine diastolic blood pressure. The majority of the blood pressure reduction occurred within the first week of treatment, indicating a rapid onset of action. The study also revealed that the placebo group experienced a significant decrease in blood pressure, highlighting the importance of considering placebo effects in clinical trials.

Managing High Blood Pressure with Guanabenz

This research suggests that guanabenz acetate is an effective and well-tolerated medication for managing high blood pressure. The study's findings underscore the importance of considering both medication effects and placebo effects in clinical trials. Individuals with hypertension should consult with their healthcare providers to determine the most appropriate treatment plan, taking into account individual factors and potential side effects. Living a healthy lifestyle, including regular exercise and a balanced diet, can also play a significant role in managing blood pressure and maintaining overall health.

Dr.Camel's Conclusion

High blood pressure is like a desert wind, relentless and capable of causing damage. Guanabenz offers a potential oasis, helping to control this invisible threat. It's important to remember that while medication can play a crucial role, a healthy lifestyle is essential for overall well-being. So, keep those blood pressure numbers in check, and remember to take care of yourself!

Date :
  1. Date Completed 1980-12-18
  2. Date Revised 2017-02-14
Further Info :

Pubmed ID

7418949

DOI: Digital Object Identifier

10.1177/030006058000800501

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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