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A kinetically based logical approach to the chemotherapy of head and neck cancer.

Author: HillB T, PriceL A

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Chemotherapy with or without adriamycin was effective in treating advanced head and neck cancer, with a higher response rate in the group receiving adriamycin.
Paper Details　
Original Abstract of the Article :
The application of some basic principles derived from studies of the cell cycle and proliferative kinetics of normal and malignant cells has provided a rational basis for designing cancer treatment protocols. Using this approach in advanced head and neck cancer it is possible (a) to increase the res...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://doi.org/10.1111/j.1365-2273.1977.tb01377.x

データ提供：米国国立医学図書館（NLM）

A Logical Approach to Chemotherapy in Head and Neck Cancer

In the world of oncology, where the fight against cancer is waged, head and neck cancer presents a significant challenge. This research explores a rational and logical approach to chemotherapy for advanced head and neck cancer, aiming to optimize treatment outcomes. The study involved 71 patients with advanced head and neck cancer who were randomly assigned to receive one of two combination chemotherapy regimens, one with and one without adriamycin. The researchers meticulously observed the patients' responses to treatment, recording the effectiveness and side effects.

A Rational Approach to Chemotherapy

This study demonstrates the effectiveness of a combination chemotherapy approach for advanced head and neck cancer, emphasizing the importance of designing treatment regimens based on the principles of cell cycle kinetics and proliferative kinetics. This approach, grounded in scientific understanding, provides a logical framework for optimizing treatment outcomes. Think of it like navigating a desert, understanding the terrain and weather patterns to choose the most efficient and safe route.

The Role of Prior Radiotherapy

The study also highlighted the impact of prior radiotherapy on the effectiveness of chemotherapy. Patients who had received prior radiotherapy were less likely to respond to chemotherapy. This finding underscores the importance of considering the patient's treatment history when designing a chemotherapy regimen. This is akin to understanding the impact of past environmental changes on the current state of a desert ecosystem, recognizing that past events can influence present outcomes.

Dr. Camel's Conclusion

This research journey is akin to navigating a vast desert, seeking to understand the complex interplay of factors that influence the effectiveness of cancer treatment. The study's findings highlight the importance of a rational and logical approach to chemotherapy, emphasizing the need to design treatment regimens based on scientific principles. This research provides valuable insight into the science of cancer treatment, offering a roadmap towards improved outcomes for those battling head and neck cancer.
Date :
  1. Date Completed 1978-03-21
  2. Date Revised 2019-09-07
Further Info :

Pubmed ID

74302

DOI: Digital Object Identifier

10.1111/j.1365-2273.1977.tb01377.x

Related Literature

Article Analysis
・Effective treatment of head and neck cancer
SNS
PICO Info
in preparation
Languages

English

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