In vivo and in vitro effects of methylprednisolone on human lymphocyte proliferation.

Author: WangS R, ZweimanB

Paper Details 
Original Abstract of the Article :
Lymphocytes obtained from normal volunteers 4 hr after intravenous methylprednisolone (1 mg/kg of body weight) were significantly less stimulated in vitro by several concentrations of phytohemagglutinin and concanavalin A. This effect was not due to diurnal variations. Significant decreases in the l...See full text at original site
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引用元:
https://doi.org/10.1016/0162-3109(80)90001-6

データ提供:米国国立医学図書館(NLM)

Methylprednisolone's Impact on Human Lymphocyte Proliferation

This study investigates the effects of methylprednisolone, a corticosteroid medication, on human lymphocyte proliferation. The researchers found that methylprednisolone significantly reduced lymphocyte stimulation in vitro, suggesting a direct effect on lymphocyte function. The study also suggests that methylprednisolone may influence lymphocyte distribution, contributing to its immunosuppressive effects.

Unraveling the Immunosuppressive Effects

This research provides insights into the mechanisms by which methylprednisolone exerts its immunosuppressive effects. The study's findings highlight the importance of understanding these mechanisms for optimizing the use of this medication and minimizing potential side effects.

Navigating the Immune System's Shifting Sands

The researchers likened the immune system to a vast desert landscape, where lymphocytes, the cells responsible for fighting infection, are constantly shifting and changing. Just as a traveler must adapt to the ever-changing terrain, clinicians must understand the complex dynamics of the immune system to effectively manage conditions that affect it. This study provides valuable insights into the impact of methylprednisolone on lymphocyte function, emphasizing the need for careful consideration of its potential effects on the immune system.

Dr.Camel's Conclusion

This study provides valuable insights into the effects of methylprednisolone on human lymphocyte proliferation, shedding light on its immunosuppressive mechanisms. The researchers' findings highlight the complex interactions between methylprednisolone and the immune system, emphasizing the importance of careful consideration of its potential effects. This research contributes to our understanding of the delicate balance of the immune system and the need for cautious use of immunosuppressive medications.

Date :
  1. Date Completed 1981-02-19
  2. Date Revised 2019-09-20
Further Info :

Pubmed ID

7440135

DOI: Digital Object Identifier

10.1016/0162-3109(80)90001-6

Related Literature

SNS
PICO Info
in preparation
Languages

English

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