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Discontinuing penicillin prophylaxis in children with sickle cell anemia. Prophylactic Penicillin Study II.

Author: BuchananG R, FallettaJ M, HolbrookC T, IyerR V, KinneyT R, MillerS T, PegelowC H, VerterJ I, VichinskyE, WoodsG M

Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Children with sickle cell anemia who have not had a prior severe pneumococcal infection or a splenectomy and are receiving comprehensive care may safely stop prophylactic penicillin therapy at 5 years of age.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To evaluate the consequences of discontinuing penicillin prophylaxis at 5 years of age in children with sickle cell anemia who had received prophylactic penicillin for much of their lives. DESIGN: Randomized, double-blind, placebo-controlled trial. SETTING: Eighteen teaching hospitals t...See full text at original site
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引用元：
https://doi.org/10.1016/s0022-3476(95)70154-0

データ提供：米国国立医学図書館（NLM）

Discontinuing Penicillin Prophylaxis in Children with Sickle Cell Anemia: A Randomized Controlled Trial

This double-blind, placebo-controlled trial investigated the safety of discontinuing penicillin prophylaxis in children with sickle cell anemia. Children who had received prophylactic penicillin for at least two years before their fifth birthday were randomly assigned to continue penicillin or receive a placebo. The primary outcome was the incidence of bacteremia or meningitis caused by *Streptococcus pneumoniae*.

The results showed no significant difference in the incidence of pneumococcal infection between the two groups. This suggests that children with sickle cell anemia who have not had a prior severe pneumococcal infection or splenectomy and are receiving comprehensive care may safely stop prophylactic penicillin therapy at five years of age. However, parents must be counseled to seek immediate medical attention for all febrile events in children with sickle cell anemia.

Sickle Cell Anemia: Managing Infection Risk

This study provides valuable insights into the management of infection risk in children with sickle cell anemia. While the findings suggest that penicillin prophylaxis can be safely discontinued in some cases, it is essential to maintain a high level of vigilance and seek immediate medical attention for any signs of infection.

Protecting Children with Sickle Cell Anemia: A Multifaceted Approach

The care of children with sickle cell anemia requires a multi-faceted approach. This includes regular medical checkups, vaccinations, and prompt treatment of infections. It's essential for parents and caregivers to be well-informed about the potential risks and management strategies for this complex condition.

Dr. Camel's Conclusion

This study, like a thirsty camel finding a hidden oasis in the desert, provides valuable insights into the management of sickle cell anemia. The results underscore the importance of personalized care and careful consideration of individual risk factors when making treatment decisions. As a researcher, I am always impressed by the dedication of physicians and researchers who work tirelessly to improve the lives of those living with chronic conditions.

Date :
  1. Date Completed 1995-12-14
  2. Date Revised 2019-06-30
Further Info :

Pubmed ID

7472817

DOI: Digital Object Identifier

10.1016/s0022-3476(95)70154-0

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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