Effects of penicillin v potassium: A Synthesis of Findings from 24 Studies

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Original Abstract of the Article

Main Research Findings

Penicillin V potassium is an effective treatment for pharyngitis/tonsillitis caused by Streptococcus pyogenes. 20 found that penicillin V potassium is as effective and safe as cefpodoxime proxetil in treating pharyngitis. 9 recommends penicillin V potassium as a first-line treatment for tonsillitis. 22 also found that a 10-day course of penicillin V potassium is effective in treating children with Streptococcus pyogenes tonsillopharyngitis.

Penicillin V potassium may alter the biodistribution of technetium Tc-99m gluceptate when co-administered with other drugs. 17 found that intravenous penicillamine caused a substantial increase in gallbladder and small bowel radioactivity. Oral acetaminophen and trimethoprim-sulfamethoxazole also minimally increased gallbladder radioactivity. However, oral and intravenous penicillins did not increase gallbladder activity.

Penicillin V potassium was not carcinogenic in rodents. 19 showed that penicillin V potassium administered to rats and mice for two years did not cause any cancer.

Penicillin V potassium may affect gut microbiota. 14 showed that antibiotics including penicillin V potassium can affect the composition and function of bacterial communities in the hyporheic zone sediments.

Benefits and Risks

Benefit Summary

Penicillin V potassium is effective in treating pharyngitis/tonsillitis caused by Streptococcus pyogenes. It is also non-carcinogenic. 20 , 9 , 22 , 19

Risk Summary

Penicillin V potassium may alter the biodistribution of technetium Tc-99m gluceptate when co-administered with other drugs. 17 It may also affect gut microbiota. 14 Rarely, allergic reactions can occur. 15

Comparison Across Studies

Commonalities Across Studies

Multiple studies have found penicillin V potassium to be effective in treating pharyngitis/tonsillitis caused by Streptococcus pyogenes. 20 , 9 , 22

Differences Across Studies

The impact of co-administering penicillin V potassium with other drugs varies between studies. 17 found that penicillamine affected the biodistribution of technetium Tc-99m gluceptate, but other studies did not report such effects.

Consistency and Discrepancies in the Findings

There is consistent evidence that penicillin V potassium is effective in treating pharyngitis/tonsillitis caused by Streptococcus pyogenes. 20 , 9 , 22 However, further research is needed to fully understand the potential impact of co-administering penicillin V potassium with other drugs.

Considerations for Real-World Application

When taking penicillin V potassium, follow your doctor's instructions carefully. If you are taking other medications, consult your doctor. 17 If you experience an allergic reaction, seek medical attention immediately. 15

Limitations of the Current Research

The potential effects of co-administering penicillin V potassium with other drugs need further investigation. 17 Additional research is also needed to clarify the impact on the gut microbiota. 14

Future Research Directions

Future research should investigate the potential interactions of penicillin V potassium with other drugs, its impact on the gut microbiota, and its long-term effects.

Conclusion

Penicillin V potassium is a highly effective treatment for pharyngitis/tonsillitis caused by Streptococcus pyogenes. 20 , 9 , 22 However, it is important to be aware of the potential effects of co-administering it with other drugs and its long-term use. 17 Always follow your doctor's instructions when taking penicillin V potassium. 17

Literature analysis of 24 papers
Positive Content
20
Neutral Content
2
Negative Content
2
Article Type
6
2
2
2
24
1.

Systemic antibiotics for symptomatic apical periodontitis and acute apical abscess in adults.

Author: CopeAnwen, FrancisNick, WoodFiona, MannMala K, ChestnuttIvor G

Dental pain relief
Antibiotic resistance

While clinical guidelines recommend removing the source of inflammation or infection for dental pain, antibiotics are only prescribed for spreading infections or systemic involvement. Despite this, dentists continue to prescribe antibiotics, which raises concerns about antibiotic resistance.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

2.

Treatment of lichen sclerosus with antibiotics.

Author: ShelleyWalter B, ShelleyE Dorinda, AmuraoCristine V

Lichen sclerosus treatment

Penicillin and cephalosporins are effective in treating lichen sclerosus, particularly in patients unresponsive to topical corticosteroids.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

3.

Cefaclor in treatment of otitis media and pharyngitis in children.

Author: McLinnS E

Otitis media treatment
Pharyngitis treatment
Side effects

Cefaclor was more effective than amoxicillin trihydrate for otitis media, especially in cases caused by Haemophilus influenzae, but the difference was not statistically significant. Cefaclor was well tolerated with no serious side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

4.

Insufficient evidence of the effect of systemic antibiotics on adults with symptomatic apical periodontitis or acute apical abscess.

Author: Veitz-KeenanAnalia, De BartoloAngela M

Dental health research

This study reviewed various databases for evidence on the effectiveness of fluoride varnish for preventing dental caries in children.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
CommentA short article/note that provides an opinion/perspective/interpretation on a published paper/topic.

Language : English

5.

Once-daily cefadroxil versus oral penicillin in the pediatric treatment of streptococcal pharyngitis.

Author: GoldfarbJ, LemonE, O'HoroJ, BlumerJ L

Pharyngitis treatment
Relapse

Cefadroxil and penicillin V potassium were equally effective in treating pharyngitis, with cure rates of 100% and 88%, respectively. Both treatments had low rates of side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

A study of 5-day cefdinir treatment for streptococcal pharyngitis in children. Cefdinir Pediatric Pharyngitis Study Group.

Author: TackK J, HedrickJ A, RothsteinE, NemethM A, KeyserlingC, PichicheroM E

Clinical cure of pharyngitis
Eradicated S pyogenes

A 5-day regimen of cefdinir was more effective in eradicating Streptococcus pyogenes than a 10-day regimen of penicillin V. Both regimens showed similar clinical cure rates and adverse event rates.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Water-immiscible room temperature ionic liquids (RTILs) as drug reservoirs for controlled release.

Author: JaitelyVikas, KaratasAysegül, FlorenceAlexander T

dexametasone release
pharmaceutical reservoirs
pharmaceutical solvents
sucrose release
surface activity
toxicity

Room temperature ionic liquids (RTILs) have potential as pharmaceutical solvents and reservoirs. The study investigated the properties of hexafluorophosphate salts of different imidazolium cations and their ability to release drugs into water.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Clinical practice guideline: tonsillitis I. Diagnostics and nonsurgical management.

Author: WindfuhrJochen P, ToepfnerNicole, SteffenGregor, WaldfahrerFrank, BernerReinhard

Tonsillitis treatment

This guideline provides a multi-disciplinary approach to managing acute tonsillitis, focusing on conservative treatment options. It recommends using a diagnostic scoring system to identify β-hemolytic streptococci and outlines appropriate antibiotic regimens. The guideline also emphasizes the importance of avoiding unnecessary blood tests and other investigations.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Practice GuidelineGuidelines and recommendations for the diagnosis and treatment of specific medical conditions in medical practice.

Language : English

11.

Discontinuing penicillin prophylaxis in children with sickle cell anemia. Prophylactic Penicillin Study II.

Author: FallettaJ M, WoodsG M, VerterJ I, BuchananG R, PegelowC H, IyerR V, MillerS T, HolbrookC T, KinneyT R, VichinskyE

Safe to stop penicillin prophylaxis
Nausea
Penicillin resistance
Pneumococcal infection
Vomiting

Children with sickle cell anemia who have not had a prior severe pneumococcal infection or a splenectomy and are receiving comprehensive care may safely stop prophylactic penicillin therapy at 5 years of age.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

15.

Lack of penicillin resensitization in patients with a history of penicillin allergy after receiving repeated penicillin courses.

Author: SolenskyRoland, EarlHarry S, GruchallaRebecca S

Accurate penicillin allergy test
Resensitization

Penicillin skin tests are highly accurate in identifying individuals who can safely receive penicillin.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

16.

Clostridium difficile colitis mimicking acute peritonitis.

Author: DrapkinM S, WorthingtonM G, ChangT W, RazviS A

Avoid unnecessary laparotomy
Antibiotic-associated colitis

Antibiotic-associated colitis, caused by Clostridium difficile, should be considered in any patient developing peritoneal signs while or after receiving antibiotics. Five patients receiving penicillin V potassium or a cephalosporin developed fever, leukocytosis, and right-lower-quadrant peritoneal irritation, requiring emergency laparotomy. Early proctosigmoidoscopy or stool examination may help avoid unnecessary surgery.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

17.

Effects of concurrent drug therapy on technetium Tc-99m gluceptate biodistribution.

Author: HinkleG H, BasmadjianG P, PeekC, BarkerK K, IceR D

Altered biodistribution

Penicillamine may significantly alter the biodistribution of technetium Tc-99m gluceptate, potentially affecting the accuracy of gallbladder imaging.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

18.

Treatment of patients with acute recurrent tonsillitis due to group A beta-haemolytic streptococci: a prospective randomized study comparing penicillin and amoxycillin/clavulanate potassium.

Author: BrookI

Prevention of recurrent infection
Tonsillitis treatment

Amoxycillin/clavulanate potassium was more effective than penicillin-V potassium in treating acute episodes of recurrent streptococcal tonsillitis and preventing recurrent infection.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

20.

Comparison of oral cefpodoxime proxetil and penicillin V potassium in the treatment of group A streptococcal pharyngitis/tonsillitis. The Cefpodoxime Pharyngitis Study Group.

Author: BrownR J, BattsD H, HughesG S, GreenwaldC A

Effective pharyngitis treatment
Safe pharyngitis treatment
Diarrhea
Nausea

Cefpodoxime proxetil (100 mg every 12 hours) was as effective and safe as penicillin V potassium (250 mg every 6 hours) in treating pharyngitis due to Streptococcus pyogenes. After 10 days of treatment, 97% of patients in each group achieved clinical cure or improvement. While 29 out of 30 cefpodoxime-treated patients and 30 out of 33 penicillin-treated patients had S. pyogenes eradicated from their throat culture, the infection recurred in one patient from each group 20 days after treatment termination. The most common adverse events were nausea and diarrhea, which occurred in 7 cefpodoxime-treated patients and 2 penicillin-treated patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

22.

Effective short-course treatment of acute group A beta-hemolytic streptococcal tonsillopharyngitis. Ten days of penicillin V vs 5 days or 10 days of cefpodoxime therapy in children.

Author: PichicheroM E, GoochW M, RodriguezW, BlumerJ L, AronoffS C, JacobsR F, MusserJ M

Cefpodoxime efficacy
Cefpodoxime well-tolerated

Cefpodoxime was more effective than penicillin V in treating acute group A beta-hemolytic streptococcal tonsillopharyngitis in children. A 5-day course of cefpodoxime was as effective as a 10-day course.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

23.

Systemic antibiotics for symptomatic apical periodontitis and acute apical abscess in adults.

Author: CopeAnwen L, FrancisNick, WoodFiona, ChestnuttIvor G

Dental pain relief
Antibiotic resistance

This review updates a 2014 publication on the treatment of dental pain due to apical periodontitis and acute apical abscess. The review highlights the recommended first-line treatment, which involves removing the source of inflammation or infection. Systemic antibiotics are only recommended for spreading or systemic infections. The review expresses concern about the frequent prescription of antibiotics in the absence of these signs, as it contributes to antibiotic resistance.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

24.

Incidence of beta-lactam-induced delayed hypersensitivity and neutropenia during treatment of infective endocarditis.

Author: OlaisonL, BelinL, HogevikH, AlestigK

Safe penicillin re-treatment
Adverse reactions
Neutropenia

Long-term parenteral beta-lactam treatment has a high incidence of adverse reactions, particularly after 2 weeks. Penicillin G is the most common culprit.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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