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A preliminary trial of lamivudine for chronic hepatitis B infection.
Author: BartholomewM, DienstagJ L, PerrilloR P, RubinM, SchiffE R, VicaryC
Original Abstract of the Article :
BACKGROUND: Better treatments for chronic hepatitis B are needed. Lamivudine, the (-)enantiomer of 3'-thiacytidine, is a potent inhibitor of hepatitis B virus (HBV). METHODS: In a double-blind trial, we randomly assigned 32 patients with chronic hepatitis B (including 17 who had no response to earl...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1056/NEJM199512213332501
データ提供:米国国立医学図書館(NLM)
A New Hope for Chronic Hepatitis B: Lamivudine Shows Promise
The field of [hepatitis B treatment] is always searching for better ways to help those suffering from chronic hepatitis B. This research delves into the potential of [lamivudine], a potent inhibitor of hepatitis B virus (HBV), as a treatment option. Using a [double-blind trial] design, researchers assigned 32 patients to receive different doses of lamivudine. The results were quite promising – in a vast majority of patients, HBV DNA became undetectable, showcasing the potential of this drug. While the virus reappeared in most after treatment ended, a significant portion of patients, including those who had not responded to earlier treatments, had sustained suppression of HBV DNA. This finding suggests that lamivudine could be a valuable tool for managing chronic hepatitis B, especially for those who haven't found relief with other treatments.
Lamivudine: A Potential Game-Changer for Hepatitis B Treatment
The success rate of lamivudine in reducing HBV DNA to undetectable levels, especially in patients who were previously unresponsive to other treatments, is a significant breakthrough. These results strongly suggest that lamivudine could be a valuable tool for managing chronic hepatitis B, providing hope for many individuals battling this persistent disease. It's important to note that while most patients saw a return of the virus, a significant number did experience sustained suppression, paving the way for further investigation into long-term treatment strategies.
Living with Hepatitis B: What Does Lamivudine Mean for You?
This research shines a light on the potential of lamivudine as a treatment option for chronic hepatitis B. While further research is needed to fully understand its long-term effects, the results are encouraging, suggesting that it could offer a new avenue for managing this complex condition. It's crucial to consult with your doctor to discuss whether lamivudine is the right treatment for you, as they can provide tailored advice based on your individual needs and medical history.
Dr.Camel's Conclusion
Lamivudine is like a cool oasis in the vast desert of hepatitis B research! While more research is needed, this study's results bring hope for better treatment options for those with chronic hepatitis B. Like a camel trekking across the desert, we must continue to explore the possibilities and strive to find the best solutions for those affected by this disease.
Date :
- Date Completed 1995-12-21
- Date Revised 2013-11-21
Further Info :
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