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[Fibrinolytic inhibitors and prevention of bleeding in cardiac valve surgery. Comparison of tranexamic acid and high dose aprotinin].

Author: BenmosbahL, BoughenouF, CarpentierA, CousinM T, Madi-JebaraS, Massonnet-CastelS

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This randomized study compared the effects of tranexamic acid and high-dose aprotinin on postoperative bleeding in cardiac surgery patients. Both treatments effectively controlled bleeding, with comparable outcomes and safety profiles. The study suggests that tranexamic acid can be a safe and effective alternative to high-dose aprotinin in cardiac surgery.
Paper Details　
Original Abstract of the Article :
In order to assess the effects of tranexamic acid in comparison to the high dose regimen of aprotinin recommended by Royston and considered to be the reference in postoperative bleeding in cardiac surgery, 35 consecutive patients were randomised to two groups according to the product prescribed. The...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/7487290

データ提供：米国国立医学図書館（NLM）

Tranexamic Acid: A Reliable Alternative in Cardiac Surgery

Cardiac surgery is a delicate procedure, and controlling bleeding is a crucial factor for a successful outcome. This research focuses on the role of fibrinolytic inhibitors, which are like tiny soldiers that stop bleeding by preventing the breakdown of blood clots. The study compares tranexamic acid, a commonly used fibrinolytic inhibitor, with a high-dose regimen of aprotinin, a more traditional approach. They found that tranexamic acid was equally effective in controlling bleeding while being just as safe as aprotinin, indicating that it could be a valuable alternative in cardiac surgery.

A Safety and Efficacy Win for Tranexamic Acid

The study demonstrates that tranexamic acid effectively reduces postoperative bleeding in cardiac surgery with no increased risk of thrombotic complications. Furthermore, it conserves platelet protection, making it a reliable and safe choice for cardiac surgeons.

Minimizing Bleeding and Optimizing Recovery

This research sheds light on a new and effective way to manage bleeding during cardiac surgery. Tranexamic acid's safety and efficacy profile makes it a promising option for surgeons, potentially leading to faster recovery times and better overall outcomes for patients undergoing this procedure.

Dr.Camel's Conclusion

Just as the desert sands shift and change, the landscape of cardiac surgery is evolving with new approaches. This study offers a valuable insight, revealing that tranexamic acid is a worthy contender in the world of fibrinolytic inhibitors, offering a safe and effective way to manage bleeding after heart surgery.

Date :
  1. Date Completed 1995-12-05
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

7487290

DOI: Digital Object Identifier

7487290

SNS
PICO Info
in preparation
Languages

French

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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