Paper Details

  1. Home
  2. Paper Details

Flurbinitroxybutylester: a novel anti-inflammatory drug has enhanced antithrombotic activity.

Author: BaydounA R, CicalaC, CirinoG, MancusoF, WallaceJ L

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.

Overview

This study investigates the anti-thrombotic potential of Flurbi-NO, a modified flurbiprofen derivative. Flurbi-NO demonstrated greater potency in inhibiting collagen-induced platelet aggregation than flurbiprofen, likely due to nitric oxide release. The study highlights the potential of Flurbi-NO as an anti-thrombotic agent with reduced gastrointestinal side effects.
Paper Details　
Original Abstract of the Article :
We have recently shown that the introduction of a nitroxybutylester moiety into flurbiprofen, to form Flurbi-NO, results in a compound with markedly reduced undesired effects in the gastrointestinal tract. This effect has been shown to be linked to nitric oxide release from the Flurbi-NO. Here we ha...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/0049-3848(95)00092-6

データ提供：米国国立医学図書館（NLM）

Flurbi-NO: A Novel Anti-inflammatory Drug with Enhanced Antithrombotic Properties

The world of drug development is always seeking to improve existing therapies. This study investigates the potential benefits of [specific drug] as an anti-inflammatory and antithrombotic agent. The authors [study design] to compare [specific drug] with a conventional anti-inflammatory drug. Their findings suggest that [specific drug] may offer a unique therapeutic advantage by combining anti-inflammatory properties with enhanced antithrombotic effects, potentially mitigating the risk of gastrointestinal side effects. This research could lead to the development of new and safer therapeutic options for patients with inflammatory conditions and a risk of thrombosis.

Flurbi-NO: A Promising New Therapeutic

This research underscores the potential of Flurbi-NO as a promising new therapeutic for inflammatory conditions. The study found that [specific result], demonstrating the effectiveness of Flurbi-NO in inhibiting platelet aggregation and reducing the risk of thromboembolism. The authors highlight the potential of this drug to offer a safer alternative to conventional anti-inflammatory drugs, particularly for patients at risk for gastrointestinal complications. This research could lead to the development of new and safer therapeutic options for patients with inflammatory conditions and a risk of thrombosis.

Flurbi-NO: A Safer Option for Patients

This study emphasizes the potential benefits of Flurbi-NO for patients with inflammatory conditions. The findings suggest that [specific benefit] could potentially improve patient outcomes and minimize the risk of side effects. It's a reminder that ongoing research in drug development is crucial for finding safer and more effective treatments for patients with diverse health needs.

Dr.Camel's Conclusion

This research presents a compelling case for Flurbi-NO as a potential new therapeutic for inflammatory conditions. The study highlights the importance of innovative drug design and development in addressing unmet medical needs, particularly in areas where existing treatments have limitations. The authors encourage further research to fully evaluate the safety and efficacy of Flurbi-NO in clinical settings.

Date :
  1. Date Completed 1996-01-11
  2. Date Revised 2019-07-27
Further Info :

Pubmed ID

7495106

DOI: Digital Object Identifier

10.1016/0049-3848(95)00092-6

Related Literature

Article Analysis
・Side Effects of flurbiprofen
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.