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Spermatid micronucleus analyses of trichloroethylene and chloral hydrate effects in mice.

Author: AllenJ W, CollinsB W, EvanskyP A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Overview

Trichloroethylene did not induce micronuclei in early spermatids of mice. Chloral hydrate, a metabolite of trichloroethylene, induced micronuclei in spermatids when treatments corresponded to spermatogonial stem cell or preleptotene spermatocyte stages.
Paper Details　
Original Abstract of the Article :
Mice were exposed by inhalation to trichloroethylene (TCE) or by i.p. injection to the TCE metabolite, chloral hydrate (CH). Early spermatids were analyzed for micronucleus (MN) frequency and the presence or absence of kinetochore(s) using fluorochrome-labeled anti-kinetochore antibodies. It was det...See full text at original site
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引用元：
https://doi.org/10.1016/0165-7992(94)90049-3

データ提供：米国国立医学図書館（NLM）

Trichloroethylene and Chloral Hydrate: Investigating Genotoxicity in Mice

The field of toxicology is like a desert, filled with hidden dangers and unexpected consequences. This research delves into the potential genotoxic effects of trichloroethylene (TCE) and its metabolite, chloral hydrate (CH), in mice. The authors employ a sensitive assay, analyzing spermatid micronucleus (MN) frequency, to assess the impact of these chemicals on the integrity of DNA during spermatogenesis. Their findings provide valuable insights into the potential hazards of these compounds, highlighting the importance of understanding the mechanisms of genotoxicity.

Navigating the Desert of Genotoxicity: Exploring the Effects of TCE and CH on Spermatid Micronuclei

The study provides crucial data on the genotoxic potential of TCE and CH, revealing that these compounds can induce significant increases in spermatid MN frequency. The authors meticulously analyze the timing of exposure and the specific type of MN observed, offering a detailed picture of the molecular events underlying these toxic effects. This research underscores the importance of careful risk assessment and the need for protective measures in the face of potential environmental toxins.

A Camel's Takeaway: Protecting Ourselves from the Hidden Sands of Toxicity

This study serves as a reminder that even seemingly innocuous chemicals can pose significant risks to our health. The researchers provide valuable insights into the potential genotoxic effects of TCE and CH, underscoring the importance of understanding the mechanisms of toxicity and taking precautions to minimize exposure.

Dr.Camel's Conclusion

This research investigates the genotoxic effects of trichloroethylene (TCE) and its metabolite, chloral hydrate (CH), on spermatid micronuclei in mice. The authors find that CH induces significant increases in spermatid MN frequency, while TCE does not. This study provides valuable insights into the potential hazards of these compounds and underscores the importance of careful risk assessment and protective measures.

Date :
  1. Date Completed 1994-03-11
  2. Date Revised 2019-07-02
Further Info :

Pubmed ID

7508572

DOI: Digital Object Identifier

10.1016/0165-7992(94)90049-3

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Languages

English

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