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Side effects of dihydropyridine therapy: comparison of amlodipine and nifedipine retard.

Author: BremnerA D, FellP J, HosieJ, JamesG V, SaulP A, TaylorS H

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Amlodipine (5 mg once daily) was more tolerable than nifedipine retard (20 mg twice daily) in 97 patients with mild-to-moderate hypertension. Both drugs reduced blood pressure effectively, but nifedipine retard was associated with more side effects.
Paper Details　
Original Abstract of the Article :
The efficacy and tolerability of amlodipine (5 mg, once daily), nifedipine retard (20 mg, twice daily), and placebo were compared in a multicenter, three-way, crossover study involving 97 patients with mild-to-moderate hypertension. Each patient underwent three, 2-week treatment periods separated by...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/7522287

データ提供：米国国立医学図書館（NLM）

Comparing Amlodipine and Nifedipine: A Tale of Two Blood Pressure Medications

In the vast and ever-expanding desert of cardiovascular research, we find a quest to understand the effects of dihydropyridine therapy on blood pressure. This study, a three-way crossover trial involving 97 patients with mild-to-moderate hypertension, delved into the efficacy and tolerability of amlodipine, nifedipine retard, and placebo. The authors employed a rigorous methodology, comparing these three treatments over a series of two-week treatment periods, separated by washout periods. This meticulous approach allowed them to draw insightful conclusions.

Unveiling the Differences: Amlodipine Emerges as the More Tolerable Choice

The results unveiled a significant finding: nifedipine retard, while effective in lowering blood pressure, was associated with a significantly greater incidence of treatment-related side effects compared to amlodipine or placebo. This difference was particularly notable in the frequency of headache and flushing, with amlodipine showing a significantly lower incidence. These findings offer a crucial piece of information for healthcare providers in their pursuit of safe and effective treatment options for hypertension.

Navigating the Side Effects: Choosing the Right Path

This research sheds light on the importance of considering individual patient characteristics and tolerance levels when prescribing dihydropyridine therapies. While both amlodipine and nifedipine retard demonstrated efficacy in lowering blood pressure, the significantly higher incidence of side effects associated with nifedipine retard makes amlodipine a more favorable choice for patients seeking a more tolerable treatment option.

Dr.Camel's Conclusion

This study, like a beacon in the desert, illuminates the importance of considering the side effect profile when selecting dihydropyridine therapies. Amlodipine, with its lower incidence of side effects, emerges as a more tolerable option for patients seeking to navigate the challenging landscape of hypertension management.

Date :
  1. Date Completed 1994-10-17
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

7522287

DOI: Digital Object Identifier

7522287

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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