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The EORTC randomized trial on three fractions per day and misonidazole in advanced head and neck cancer: prognostic factors.

Author: ArcangeliG, De VilhenaM, HoriotJ C, SchraubS, SvobodaV, Van den BogaertW, de PauwM, van GlabbekeM, van der SchuerenE

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

A study comparing multiple fractions per day (MFD) radiation therapy with or without misonidazole to conventional fractionation for advanced head and neck cancer did not find significant differences in treatment results. However, it identified key factors influencing prognosis, such as performance status, tumor site, stage, and volume.
Paper Details　
Original Abstract of the Article :
In trial no. 22811 on a randomized comparison of multiple fractions per day (MFD), with or without misonidazole, to conventional fractionation in advanced head and neck cancer, a large number (523) of patients was entered in a short period of time. No differences in treatment results were obtained, ...See full text at original site
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引用元：
https://doi.org/10.1016/0167-8140(95)01539-s

データ提供：米国国立医学図書館（NLM）

Head and Neck Cancer: A Desert of Complex Treatment Decisions

Head and neck cancer, like a sandstorm, can be a formidable challenge, requiring meticulous treatment planning. This study delves into the complex world of radiation therapy for advanced head and neck cancer, exploring the effectiveness of different fractionation schedules and the role of the drug misonidazole. The study, like a seasoned explorer, analyzes a vast dataset of patient outcomes, seeking to identify factors that influence survival and treatment success.

Factors Influencing Survival: Navigating the Desert of Head and Neck Cancer

The study reveals that several factors, like a series of treacherous sand dunes, can significantly impact survival and locoregional control in head and neck cancer. These factors include performance status, tumor site, staging, and volume. The researchers, like skilled navigators, unveil the complex interplay of these factors, providing valuable insights for treatment planning and improving patient outcomes. This research underscores the importance of a multifaceted approach to head and neck cancer treatment, taking into account the unique characteristics of each case.

Making Informed Decisions in the Head and Neck Cancer Desert

This study provides a roadmap through the desert of head and neck cancer treatment. The findings highlight the crucial role of considering multiple factors, such as performance status, tumor site, and staging, when determining the optimal treatment strategy. This knowledge empowers patients and their doctors to make informed decisions, navigating this challenging terrain with greater confidence and hope for a successful outcome.

Dr.Camel's Conclusion

This research reminds us that head and neck cancer treatment is a complex desert journey, requiring careful planning and a multi-faceted approach. The study's findings offer valuable insights for navigating this challenging terrain, providing a path toward more effective treatment and improved outcomes for patients.

Date :
  1. Date Completed 1995-10-25
  2. Date Revised 2019-08-30
Further Info :

Pubmed ID

7569017

DOI: Digital Object Identifier

10.1016/0167-8140(95)01539-s

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Article Analysis
・Effective treatment of head and neck cancer
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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