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Calcium channel blockade (isradipine) in treatment of hypertension in pregnancy: a randomized placebo-controlled study.

Author: AnderssonK E, FormanA, IngemarssonI, LindbergB, LindebergS, LunellN O, MarsàlK, SkajaaK, Wide-SwenssonD H

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Isradipine was effective for treatment of nonproteinuric hypertension but not in preeclampsia.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: Our purpose was to study the effects of isradipine, a dihydropyridine calcium channel blocker, on mother and fetus in the treatment of hypertensive disorders of pregnancy. STUDY DESIGN: The investigation was performed as a two-group, parallel, double-blind multicenter study of isradipine...See full text at original site
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引用元：
https://doi.org/10.1016/0002-9378(95)90357-7

データ提供：米国国立医学図書館（NLM）

Calcium Channel Blockade: A Promising Treatment for Hypertension in Pregnancy

Hypertension during pregnancy is a serious medical condition that can pose risks to both mother and fetus. This randomized placebo-controlled study investigated the effectiveness of isradipine, a calcium channel blocker, in treating hypertensive disorders of pregnancy. The study found that isradipine effectively lowered maternal blood pressure in women with nonproteinuric hypertension but was not effective in treating preeclampsia. The study also found that isradipine was well tolerated and had few side effects. These findings suggest that calcium channel blockade with isradipine may be a safe and effective treatment option for certain types of hypertension in pregnancy.

Navigating Hypertension in Pregnancy: A New Tool

This study provides valuable evidence supporting the use of isradipine, a calcium channel blocker, in the management of nonproteinuric hypertension during pregnancy. The findings demonstrate that isradipine effectively lowers maternal blood pressure, potentially improving outcomes for both mother and fetus. However, the study also highlights that isradipine is not effective in treating preeclampsia, underscoring the need for specific treatments for different types of hypertensive disorders.

A Safe and Effective Treatment Option

This research contributes to the growing body of knowledge about safe and effective treatment options for hypertension in pregnancy. While further research is needed, the study findings suggest that calcium channel blockade with isradipine may be a valuable tool in the management of certain types of hypertensive disorders during pregnancy. This could lead to improved outcomes and reduced risks for both mother and fetus.

Dr. Camel's Conclusion

Just as a camel can navigate the harsh desert environment, this research provides a safe and effective way to navigate the challenges of hypertension during pregnancy. The study findings suggest that isradipine, a calcium channel blocker, can be a valuable tool in managing this complex condition, offering hope for healthier outcomes for both mother and child.

Date :
  1. Date Completed 1995-10-26
  2. Date Revised 2019-06-15
Further Info :

Pubmed ID

7573260

DOI: Digital Object Identifier

10.1016/0002-9378(95)90357-7

Related Literature

Article Analysis
・Side Effects of isradipine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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