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Rationale, design, and conduct of the PEPI Trial. Postmenopausal Estrogen/Progestin Interventions.

Author: BushT L, EspelandM A, JohnsonS, Mebane-SimsI, SherwinR, StefanickM L, WaclawiwM

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study investigates the potential effectiveness of estrogen and estrogen/progestin regimens in altering risk factors for cardiovascular disease in women.
Paper Details　
Original Abstract of the Article :
There is growing and consistent evidence that estrogen use in postmenopausal women is associated with a substantial reduction in the occurrence of cardiovascular disease. However, remarkably little is known about the biological mechanisms by which estrogen therapy may influence risk. Even less infor...See full text at original site
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引用元：
https://doi.org/10.1016/0197-2456(94)00033-y

データ提供：米国国立医学図書館（NLM）

PEPI Trial: Unveiling the Impact of Estrogen and Progestin on Cardiovascular Health

This paper provides a detailed overview of the Postmenopausal Estrogen/Progestin Interventions (PEPI) Trial, a groundbreaking study designed to investigate the effects of estrogen and estrogen-progestin therapy on cardiovascular risk factors in postmenopausal women. The authors, like meticulous researchers meticulously planning an expedition through the complex terrain of women's health, designed this large-scale trial to understand the impact of hormonal therapy on multiple biological systems. They aimed to provide valuable insights into the potential benefits and risks of estrogen and estrogen-progestin therapy, guiding clinical practice and informing patient decisions.

Uncovering the Complexities of Hormonal Therapy

The PEPI Trial, akin to a monumental desert expedition, sought to unravel the complex interplay between hormonal therapy and cardiovascular health. The authors recognized the need for a large-scale study to address the limitations of existing research and provide a more comprehensive understanding of the potential effects of estrogen and progestin therapy. They aimed to investigate the impact of these hormones on a range of biological systems, including the cardiovascular, skeletal, and metabolic systems.

Guiding Clinical Practice and Patient Choices

The findings of the PEPI Trial, like a valuable treasure discovered in the desert, hold the potential to guide clinical practice and inform patient choices regarding hormonal therapy. The study's results will provide valuable insights into the risks and benefits of estrogen and estrogen-progestin therapy, empowering women to make informed decisions about their health and well-being.

Dr. Camel's Conclusion

The PEPI Trial represents a significant contribution to the field of women's health, offering valuable insights into the impact of hormonal therapy on cardiovascular health. The authors' meticulous design and comprehensive approach, akin to a well-planned desert expedition, provide a solid foundation for understanding the complex relationship between hormones, cardiovascular risk factors, and overall health. The study's findings will undoubtedly guide clinical practice and empower women to make informed decisions regarding their health.

Date :
  1. Date Completed 1995-12-12
  2. Date Revised 2019-10-23
Further Info :

Pubmed ID

7587218

DOI: Digital Object Identifier

10.1016/0197-2456(94)00033-y

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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