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Mucosal pharmacokinetics and pilot study of short course of parenteral imipenem in the eradication of Helicobacter pylori.

Author: ChanR C, ChengA F, ChungS C, HoskingS W, LiA K, LingT K, SungJ J, YungM Y

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

While imipenem/cilastatin initially cleared Helicobacter pylori infection in 91% of patients with duodenal ulcers, the infection recurred in 86.3% at 8 weeks. This indicates that the combination with omeprazole was not effective in eradicating H. pylori infection.
Paper Details　
Original Abstract of the Article :
Eradication of Helicobacter pylori infection is known to reduce the incidence of duodenal ulcer recurrence. The most commonly used regimen for H. pylori infection is triple antimicrobial therapy for 1-2 weeks. This treatment is associated with frequent side effects and hence unsatisfactory complianc...See full text at original site
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引用元：
https://doi.org/10.1111/j.1440-1746.1995.tb01050.x

データ提供：米国国立医学図書館（NLM）

Imipenem: A Short-Course Approach to Eradicating Helicobacter pylori

Helicobacter pylori (H. pylori) infection, like a persistent desert parasite, can cause ulcers and other gastrointestinal problems. This study, like a dedicated gastroenterologist, investigates the potential of imipenem, an antibiotic, to eradicate this stubborn infection.

The researchers, with the patience of desert explorers, studied the pharmacokinetics of imipenem in the gastric milieu and its efficacy in eradicating H. pylori infection. They meticulously monitored drug levels in serum, gastric secretion, and gastric mucosa, like a skilled tracker following the trail of a hidden oasis.

The findings revealed that imipenem, like a powerful desert weapon, achieved high concentrations in the gastric environment, exceeding the minimum inhibitory concentration for H. pylori. However, despite this initial success, the eradication rate at 8 weeks was disappointing, suggesting that imipenem alone may not be sufficient to effectively eliminate H. pylori infection.

A Challenging Journey to Eradication

This study highlights the challenge of eradicating H. pylori infection, emphasizing the need for effective and sustained therapy. It's like navigating a desert filled with persistent parasites, requiring a multi-faceted approach to ensure success.

Exploring New Strategies for H. pylori Treatment

This research encourages further exploration of new strategies for managing H. pylori infection, seeking more effective and durable treatments to combat this persistent pathogen. It's like searching for a hidden oasis in the desert, seeking a lasting solution to this challenging health condition.

Dr. Camel's Conclusion

This study demonstrates the potential of imipenem for treating H. pylori infection. It's like finding a new weapon in the desert of gastrointestinal diseases, but further research is needed to refine its effectiveness and ensure a lasting victory against this stubborn pathogen.

Date :
  1. Date Completed 1995-08-29
  2. Date Revised 2019-08-30
Further Info :

Pubmed ID

7620110

DOI: Digital Object Identifier

10.1111/j.1440-1746.1995.tb01050.x

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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