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Short term effects of pravastatin on blood pressure in hypercholesterolaemic hypertensive patients.

Author: ConwayE L, HowesL G, KrumH, LamW, LouisW J, O'CallaghanC J, SkibaM A

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Pravastatin reduced plasma lipids in hypertensive hypercholesterolaemic patients but did not enhance the blood pressure lowering action of antihypertensive therapy.
Paper Details　
Original Abstract of the Article :
In this study, which was primarily designed to determine the lipid-lowering efficacy of pravastatin in the setting of background antihypertensive therapy with ACE inhibitors and calcium antagonists, we took the opportunity to examine whether pravastatin interacts with antihypertensive therapy to pro...See full text at original site
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引用元：
https://doi.org/10.3109/08037059409102294

データ提供：米国国立医学図書館（NLM）

Pravastatin and Blood Pressure: Exploring Interactions

High cholesterol and high blood pressure are two common health issues that can significantly increase the risk of heart disease. This research, like a physician examining the complex interplay of different medications, explores the effects of pravastatin, a cholesterol-lowering medication, on blood pressure in patients already taking antihypertensive medications. The researchers conducted a double-blind, placebo-controlled study to assess whether pravastatin could influence blood pressure in patients already receiving treatment for hypertension.

Separate But Equal: A Tale of Two Medications

The study's findings indicate that pravastatin does not significantly affect blood pressure in patients already taking antihypertensive medications. The researchers observed that pravastatin effectively lowered cholesterol levels without altering blood pressure readings. This finding, like two separate paths converging in the desert, suggests that these medications can be used safely and effectively together.

Managing Cardiovascular Health: A Multifaceted Approach

This research highlights the importance of a multi-faceted approach to managing cardiovascular health. The researchers emphasize that cholesterol-lowering medications and blood pressure-lowering medications can work independently to reduce the risk of heart disease. This understanding, like a map guiding us through the desert of cardiovascular health, allows for more precise and tailored treatment plans.

Dr. Camel's Conclusion

This research clarifies that pravastatin can be used safely and effectively to lower cholesterol levels in patients already taking antihypertensive medications, reinforcing the importance of a multi-faceted approach to managing cardiovascular health. The researchers' findings provide valuable information for clinicians seeking to optimize treatment strategies and improve patient outcomes.
Date :
  1. Date Completed 1995-05-08
  2. Date Revised 2022-04-10
Further Info :

Pubmed ID

7704289

DOI: Digital Object Identifier

10.3109/08037059409102294

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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