An evaluation of the teratogenicity of certain antinauseant drugs.

Author: MilkovichL, van den BergB J

Paper Details 
Original Abstract of the Article :
In a large, prospective, observational study of pregnancy and child development, the antinauseant drugs prescribed to gravides for nausea and vomiting in the first 84 days of pregnancy were evaluated for their teratogenic potential. The severe congenital anomaly rates per 100 liveborn children and t...See full text at original site
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引用元:
https://doi.org/10.1016/0002-9378(76)90601-3

データ提供:米国国立医学図書館(NLM)

Antinauseant Drugs: Navigating the Sands of Pregnancy and Teratogenicity

Pregnancy is a remarkable journey, but it can sometimes be fraught with challenges, including nausea and vomiting. Antinauseant drugs are often prescribed to alleviate these symptoms, but their potential impact on fetal development is a crucial consideration. This large-scale observational study investigates the teratogenic potential of various antinauseant drugs, analyzing their effects on pregnancy outcomes and child development.

Finding the Oasis of Safety

The researchers found no significant association between the use of phenothiazine derivatives, meclizine, cylizine, and Bendectin and increased rates of severe congenital anomalies or perinatal death. This is like finding a safe oasis in the desert of pregnancy, where certain antinauseant medications appear to be safe for use. However, the study did suggest a slight increase in severe congenital anomalies associated with the use of trimethobenzamide. It's important to note that this finding requires further investigation to confirm its significance.

Pregnancy: Making Informed Choices

Pregnancy is a delicate balance, and making informed decisions about medication use is crucial. It's essential to consult with your doctor to discuss your individual needs and weigh the potential risks and benefits of different medications. Remember, just as a desert traveler must make careful choices to ensure their survival, you must work with your healthcare provider to navigate the sands of pregnancy with confidence and safety.

Dr. Camel's Conclusion

This study provides valuable information for pregnant women and healthcare professionals seeking to manage nausea and vomiting safely. While the majority of antinauseant medications appear to be safe, it's important to approach medication use during pregnancy with caution and to seek guidance from a qualified healthcare professional. Remember, navigating the desert of pregnancy requires a combination of knowledge, awareness, and responsible decision-making.

Date :
  1. Date Completed 1976-07-06
  2. Date Revised 2019-06-15
Further Info :

Pubmed ID

773181

DOI: Digital Object Identifier

10.1016/0002-9378(76)90601-3

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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