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Evaluation of effects of altered gastric pH on absorption of dapsone in healthy volunteers.

Author: BreenG A, BrocavichJ M, EtzelJ V, ForlenzaS, SchaeferP, ShahV

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

The study investigated the effect of increased gastric pH on dapsone absorption in healthy volunteers. No significant differences were found in dapsone absorption between groups receiving dapsone alone and those receiving dapsone with an antacid, suggesting that increased gastric pH has little to no effect on dapsone absorption.
Paper Details　
Original Abstract of the Article :
A prospective, randomized, crossover study was performed with seven healthy volunteers to address the effect of increased gastric pH on dapsone absorption. Subjects were randomized to receive a single 100-mg dose of dapsone or a single 100-mg dose of dapsone in addition to 30 ml of a high potency an...See full text at original site
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引用元：
https://doi.org/10.1128/AAC.38.9.2227

データ提供：米国国立医学図書館（NLM）

The Impact of Gastric pH on Dapsone Absorption

Dapsone is a medication often used to treat certain infections. This study investigated the [effect of altered gastric pH on the absorption of dapsone]. They conducted a crossover study on healthy volunteers to compare the absorption of dapsone with and without antacids. They measured dapsone concentrations in serum over time to see how the absorption was affected.

Gastric pH Doesn't Significantly Affect Dapsone Absorption

The results showed that there was no significant difference in dapsone absorption between the two groups. This suggests that increased gastric pH doesn’t significantly impact how the body absorbs dapsone. It’s like finding a hidden water source in the desert, but realizing it doesn’t significantly change the course of the journey.

Understanding Medication Absorption

This study offers valuable insights into the absorption of medications, particularly dapsone. It’s important to remember that medication absorption can be affected by a variety of factors. Understanding these factors can help healthcare providers optimize treatment plans and ensure that medications are absorbed properly.

Dr. Camel's Conclusion

This study helps us understand how gastric pH affects the absorption of dapsone. The findings suggest that antacids don’t significantly impact the absorption of dapsone, which is important information for clinicians and patients.

Date :
  1. Date Completed 1995-01-27
  2. Date Revised 2021-05-26
Further Info :

Pubmed ID

7811056

DOI: Digital Object Identifier

10.1128/AAC.38.9.2227

Related Literature

Article Analysis
・Effects of dapsone
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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