Effects of dapsone: A Synthesis of Findings from 21 Studies

  1. Home
  2. Effects of dapsone
This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Effects of dapsone: A Synthesis of Findings from 21 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Effects of dapsone: A Synthesis of Findings from 21 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to DatasetPlease check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Major Research Findings

Dapsone has been investigated for its effectiveness in various medical conditions. One study 9 reported that dapsone has anticonvulsive effects on rats with seizures in the amygdala and hippocampus. Another study 19 demonstrated that dapsone can protect against heart damage caused by doxorubicin in rats. Additionally, a study 6 found that topical dapsone can reduce both inflammatory and non-inflammatory acne lesions. On the other hand, research has also revealed potential adverse effects associated with dapsone. For example, a study reported the risk of blood disorders related to dapsone use. Another study 15 indicated that dapsone may cause drug-induced hepatitis when used for pemphigus vulgaris treatment. These findings emphasize the importance of understanding both the potential benefits and risks associated with dapsone.

Benefits and Risks

Benefit Summary

Dapsone exhibits various therapeutic properties, including antimicrobial, anti-inflammatory, and antioxidant effects. Research suggests its efficacy in addressing conditions like seizures, heart toxicity, and acne inflammation. Additionally, dapsone shows potential in mitigating the adverse effects of other medications.

Risk Summary

Dapsone carries the risk of adverse effects. Research has linked dapsone use to blood disorders and hepatitis. It's important to note that dapsone can interact with other medications. Therefore, it's crucial to adhere to the guidance of healthcare professionals when using dapsone.

Comparison Across Studies

Commonalities Across Studies

Multiple studies have consistently indicated that dapsone possesses a wide range of therapeutic effects, including antimicrobial, anti-inflammatory, and antioxidant properties. The potential for drug interactions with dapsone is also consistently mentioned across studies.

Differences Across Studies

Studies have shown variations in the effectiveness of dapsone in treating specific conditions and the incidence of adverse effects. For example, while some research suggests dapsone's efficacy in reducing heart toxicity, other studies report a potential risk of hepatitis associated with dapsone use. These discrepancies might be attributed to variations in study populations, methodologies, or dosage and duration of dapsone administration.

Consistency and Contradictions in Results

Research findings concerning dapsone exhibit both consistency and contradictions. For example, multiple studies demonstrate dapsone's effectiveness in treating seizures. However, the potential for blood disorders related to dapsone use has also been reported. These contradictions could be attributed to differences in study populations, methodologies, or the dosage and duration of dapsone administration.

Considerations for Real-World Application

While dapsone holds promise for treating various conditions, it's crucial to understand the associated risks. When using dapsone, it's essential to follow the guidance of healthcare professionals and avoid self-medication. Dapsone can interact with other medications, so it's important to consult with your doctor if you're taking other medications. The potential for individual variations in response to dapsone should also be considered.

Limitations of Current Research

Research on dapsone is still ongoing and there are limitations to current research findings. For example, there's a need for further investigation into the long-term effects of dapsone and the mechanisms underlying its potential adverse effects. The potential for individual variations in response to dapsone also warrants further exploration.

Directions for Future Research

Further research on dapsone is crucial, particularly in areas such as long-term effects, the mechanisms of potential adverse effects, and the development of individualized predictive models for response and adverse effects. These research endeavors would enhance the understanding and safe application of dapsone in medical practice.

Conclusion

Dapsone exhibits promising therapeutic potential for various conditions but it's crucial to recognize its associated risks. It's essential to follow healthcare professional's guidance, avoid self-medication, and be aware of potential drug interactions. Ongoing research is needed to better understand the long-term effects, mechanisms of adverse effects, and individual variations in response to dapsone. This will contribute to the safe and effective use of dapsone in clinical settings.

Literature analysis of 21 papers
Positive Content
17
Neutral Content
1
Negative Content
3
Article Type
1
0
0
2
21
4.

In vitro effects of MOCA and dapsone on rat hepatic and splenic immune cells.

Author: KelsoJ M, BaiC L, AhokasJ T, WrightP F

Cancer risk
Immune system suppression

This study found that MOCA, an industrial curing agent, was immunotoxic in vitro, inhibiting natural immune activities and lymphocyte proliferation. The relationship between immune effects and carcinogenicity of dapsone, a structurally related medicinal agent, remains unclear.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Harnessing the anti-inflammatory effects of topical dapsone for management of acne.

Author: KircikLeon H

Acne treatment
Scarring prevention

Topical dapsone 5% gel is a safe and effective treatment for mild-to-moderate acne vulgaris. It reduces both inflammatory and non-inflammatory lesions and enhances healing.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

7.

Antioxidant, antiinflammatory and antiapoptotic effects of dapsone in a model of brain ischemia/reperfusion in rats.

Author: Diaz-RuizAraceli, ZavalaCarlos, MontesSergio, Ortiz-PlataAlma, Salgado-CeballosHermelinda, Orozco-SuarezSandra, Nava-RuizConcepción, Pérez-NeriIván, Perez-SeverianoFrancisca, RíosCamilo

Neuroprotection

Dapsone was found to be neuroprotective in a rat model of ischemia-reperfusion injury. It reduced oxidative stress, inflammation, and apoptosis, suggesting its potential for treating ischemic stroke.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

A retrospective study of the effect of modified multi-drug therapy in Nepali leprosy patients following the development of adverse effects due to dapsone.

Author: SapkotaBishwa Raj, ShresthaKanchha, PandeyBijay, WalkerStephen L

No cases of relapse
Satisfactory fall in bacterial index
None reported

Rifampicin and clofazimine are effective treatments for leprosy patients who have to stop taking dapsone due to adverse effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

Negative observations on immunological side effects of rifampin and dapsone in mice.

Author: NagataY, KohsakaK, ItoT

Rifampin and dapsone did not significantly affect various immunological responses in mice, including antibody production, delayed-type hypersensitivity, and phagocytosis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Effects of clofazimine alone or combined with dapsone on neutrophil and lymphocyte functions in normal individuals and patients with lepromatous leprosy.

Author: van RensburgC E, GatnerE M, ImkampF M, AndersonR

Treats leprosy
Inhibits neutrophil motility

Clofazimine, an anti-leprosy drug, was found to inhibit neutrophil motility and lymphocyte transformation in vitro and in vivo. In vitro studies showed that clofazimine inhibited neutrophil motility in a dose-dependent manner, while in vivo studies showed that clofazimine decreased lymphocyte responsiveness to mitogens in normal volunteers and leprosy patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

14.

Pulmonary vascular effects of endotoxin in canine lobes pretreated with dapsone.

Author: MayersI, HurstT S, WilsonT, PrasadK, ToT, MurphyF, SaxenaA, JohnsonD

HPV preservation

This study found that dapsone prevents the loss of hypoxic pulmonary vasoconstriction (HPV) associated with endotoxin.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

15.

Dapsone in the treatment of pemphigus vulgaris: adverse effects and its importance as a corticosteroid sparing agent.

Author: QuaresmaMaria Victória, Bernardes FilhoFred, HezelJanaína, PerettiMurilo Calvo, KacBernard Kawa, Azulay-AbulafiaLuna

Pemphigus vulgaris treatment
Hepatitis

Dapsone, an adjuvant treatment for pemphigus vulgaris, can cause drug-induced hepatitis. Careful monitoring is crucial.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

16.

Mesotherapy-induced panniculitis treated with dapsone: case report and review of reported adverse effects of mesotherapy.

Author: TanJennifer, RaoBabar

Allergic reactions
Infections
Necrosis
Panniculitis

This article discusses mesotherapy, a procedure involving the injection of substances into the dermis and subcutaneous tissue. It highlights the controversy surrounding its efficacy and potential localized complications, including panniculitis.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

17.

Investigations into the haemolytic effects of dapsone therapy in leprosy patients.

Author: BalakrishnanS, KarthikeyanS, RamuG

Haemolytic effects
Increased methaemoglobin

Dapsone, a drug used to treat leprosy, can cause hemolytic anemia. The study suggests that dapsone dosage should be regulated based on body weight and not exceed 1.5 mg/kg.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

18.

Acute dapsone overdose: the effects of continuous veno-venous haemofiltration on the elimination of dapsone.

Author: MasurkarV A, EdsteinM D, GortonC J, AnsteyC M

Dapsone overdose treatment

Continuous veno-venous haemofiltration successfully reduced toxic dapsone concentrations in a 15-year-old girl who had ingested a large dose of dapsone, resulting in methaemoglobinaemia and lactic acidosis.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

19.

Cardioprotective effects of dapsone against doxorubicin-induced cardiotoxicity in rats.

Author: SheibaniMohammad, NezamoleslamiSadaf, Faghir-GhanesefatHedyeh, EmamiAmir Hossein, DehpourAhmad Reza

Cardiotoxicity Risk

Doxorubicin, a chemotherapy drug, can cause cardiac toxicity due to free radical production and inflammation. This study investigated the potential protective effects of dapsone, an anti-inflammatory and antioxidant drug, on doxorubicin-induced cardiotoxicity.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

21.

Evaluation of effects of altered gastric pH on absorption of dapsone in healthy volunteers.

Author: BreenG A, BrocavichJ M, EtzelJ V, ShahV, SchaeferP, ForlenzaS

Safe with antacids

The study investigated the effect of increased gastric pH on dapsone absorption in healthy volunteers. No significant differences were found in dapsone absorption between groups receiving dapsone alone and those receiving dapsone with an antacid, suggesting that increased gastric pH has little to no effect on dapsone absorption.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.