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Fenoprofen therapy in large-joint osteoarthritis: double-blind comparison with aspirin and longterm experience.

Author: BrookeJ W

Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Fenoprofen was more effective than aspirin in relieving osteoarthritis symptoms in 11 patients and was well tolerated for periods exceeding two years.
Paper Details　
Original Abstract of the Article :
This study, designed to evaluate fenoprofen in patients with osteoarthritis, consisted of two phases: I. A double-blind crossover comparison of fenoprofen, 200 to 600 mg every six hours, to aspirin, 325 to 975 mg every six hours; II. Longterm use of fenoprofen in an open study design. During the fir...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/781234

データ提供：米国国立医学図書館（NLM）

Fenoprofen therapy in large-joint osteoarthritis: double-blind comparison with aspirin and long-term experience

The journey through the [arthritis] desert can be long and arduous, marked by pain, stiffness, and reduced mobility. This study explores the effectiveness of [fenoprofen] in treating osteoarthritis, a common condition that affects millions of people worldwide.

Double-Blind Comparison

The researchers conducted a [double-blind crossover comparison] of fenoprofen to aspirin, a well-established treatment for osteoarthritis. This method, like carefully navigating through a maze of sand dunes, allows for a fair comparison of the two treatments, minimizing the potential for bias. The study found that both fenoprofen and aspirin were significantly better than placebo in relieving pain and stiffness. Furthermore, fenoprofen demonstrated a slight advantage over aspirin in most of the studied variables.

Long-Term Experience

The researchers also conducted a [long-term open study] to evaluate the safety and efficacy of fenoprofen over extended periods. This long-term experience, like navigating through a vast desert over many days, provides valuable information about the drug's long-term effects. The study concluded that fenoprofen was safe for long-term use, exceeding two years, and did not precipitate or aggravate chronic disorders.

Dr. Camel's Conclusion

This study offers valuable insights into the use of fenoprofen in treating osteoarthritis. The researchers' meticulous approach, employing both double-blind and long-term open studies, provides a comprehensive understanding of the drug's effectiveness and safety. Fenoprofen emerges as a promising option for patients seeking relief from the pain and stiffness associated with osteoarthritis, offering a path toward improved mobility and quality of life. Just as a camel can traverse the desert for long distances, fenoprofen can help patients navigate the challenges of osteoarthritis, providing relief and allowing them to continue their journey.
Date :
  1. Date Completed 1976-09-25
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

781234

DOI: Digital Object Identifier

781234

Related Literature

Article Analysis
・Side Effects of fenoprofen
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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