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A comparison of the effects of inhaled furosemide and ethacrynic acid on sodium-metabisulfite-induced bronchoconstriction in subjects with asthma.

Author: BennettJ, KnoxA, PavordI, PyeS, TattersfieldA, WildingP

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Equivalent diuretic doses of furosemide and ethacrynic acid were found to have similar inhibitory effects on sodium metabisulfite-induced bronchoconstriction in patients with mild asthma, suggesting that interaction with the Na/K/Cl cotransporter protein or carbonic anhydrase inhibition is not the primary mechanism for furosemide's effects in asthma.
Paper Details　
Original Abstract of the Article :
Inhaled furosemide prevents bronchoconstriction induced by a number of challenges in asthma. One approach to determine the mechanism underlying this protection has been to examine the effects of diuretics with different or overlapping pharmacologic effects. We have compared the effects of furosemide...See full text at original site
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引用元：
https://doi.org/10.1164/ajrccm.151.2.7842188

データ提供：米国国立医学図書館（NLM）

Exploring the Desert of Asthma: Unmasking the Mystery of Bronchoconstriction

Asthma, a chronic respiratory disease, is like a desert wind that can suddenly constrict the airways, making breathing difficult. This study delves into the mysteries of bronchoconstriction, investigating the effects of inhaled furosemide and ethacrynic acid on sodium metabisulfite-induced bronchoconstriction in individuals with asthma. It's like exploring the desert, examining different types of sand dunes to uncover the underlying mechanisms of this condition.

Finding the Oasis of Relief: Understanding the Effects of Diuretics

Inhaled furosemide, like a welcome oasis, offers relief from bronchoconstriction. This study investigates the mechanisms behind this protective effect by comparing furosemide with ethacrynic acid, another loop diuretic. The researchers discovered that equivalent diuretic doses of both drugs had similar inhibitory effects on sodium metabisulfite-induced bronchoconstriction. This suggests that the interaction with the Na/K/Cl cotransporter protein or carbonic anhydrase inhibition is not crucial to furosemide's effects in asthma. It's like discovering that different types of desert plants can provide similar sources of water.

Navigating the Dunes of Asthma: A Breath of Fresh Air

Understanding the mechanisms behind bronchoconstriction in asthma is essential for developing more effective treatments. This study, like a compass guiding us through the desert, provides valuable insights into the complex interplay of diuretics and bronchoconstriction. It's a step closer to finding a lasting solution for those struggling with this debilitating condition.

Dr. Camel's Conclusion

The desert of asthma can be a challenging place to navigate. This study sheds light on the intricacies of bronchoconstriction, offering valuable insights into the effects of diuretics. It's a step towards discovering new treatments and offering hope for individuals living with this chronic respiratory condition.

Date :
  1. Date Completed 1995-03-09
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

7842188

DOI: Digital Object Identifier

10.1164/ajrccm.151.2.7842188

Related Literature

Article Analysis
・Effects of ethacrynic acid
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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