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Effects of acute and chronic treatment with amoxapine and cericlamine on the sleep-wakefulness cycle in the rat.

Author: AdrienJ, HamonM, JolasT, LaineyE, MaudhuitC

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Amoxapine and cericlamine, two antidepressants, were found to have similar effects on sleep in rats, both decreasing paradoxical sleep and increasing deep slow wave sleep, particularly at lower doses. Chronic administration of amoxapine consistently reduced paradoxical sleep, while cericlamine showed tolerance. Cericlamine's effects on sleep likely stem from its serotonin reuptake inhibition, while amoxapine's more complex effects may involve its 5-HT2/5-HT3 antagonist properties.
Paper Details　
Original Abstract of the Article :
Antidepressant drugs, such as the tricyclics and the serotonin reuptake inhibitors, are well known to decrease paradoxical sleep and occasionally increase slow wave sleep in human and in animals. In order to examine whether amoxapine (a mixed NA reuptake blocker and 5-HT2/5-HT3 antagonist) and ceric...See full text at original site
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引用元：
https://doi.org/10.1016/0028-3908(94)90161-9

データ提供：米国国立医学図書館（NLM）

Exploring the Sleep-Wake Cycle: The Impact of Antidepressants

This study investigates the complex interplay between

pharmacology

and

sleep

, specifically exploring the effects of antidepressants on the sleep-wake cycle in rats. The researchers, like scientists meticulously observing the behavior of desert creatures, examined the effects of amoxapine and cericlamine, two different antidepressant medications, on sleep patterns in rats. The study found that both drugs, when administered acutely, decreased paradoxical sleep and increased deep slow wave sleep. This research provides valuable insights into the sleep-disrupting effects of certain antidepressants and their potential impact on overall well-being.

Antidepressants: Navigating the Sleep-Wake Terrain

This research highlights the complex relationship between antidepressants and sleep patterns, reminding us that the desert of mental health is not always a smooth journey. The researchers found that both amoxapine and cericlamine, like travelers encountering unexpected terrain in the desert, can disrupt sleep patterns in rats. This study underscores the importance of understanding the potential side effects of medications, particularly their impact on sleep quality and overall well-being.

A Deeper Understanding of Sleep and Mental Health

This research underscores the importance of a holistic approach to mental health, considering not only the psychological aspects but also the physiological factors, like sleep. The researchers, like explorers uncovering the hidden depths of a desert ecosystem, remind us that sleep is a crucial component of overall health and well-being. This study highlights the need for a comprehensive understanding of the interactions between medications, sleep, and mental health to ensure optimal patient outcomes.

Dr.Camel's Conclusion

This research provides valuable insights into the effects of antidepressants on sleep patterns in rats, highlighting the need for a comprehensive understanding of the interplay between medications, sleep, and mental health. The study emphasizes the importance of considering the potential side effects of medications and tailoring treatment strategies to meet the unique needs of individual patients.

Date :
  1. Date Completed 1995-03-06
  2. Date Revised 2019-07-26
Further Info :

Pubmed ID

7845548

DOI: Digital Object Identifier

10.1016/0028-3908(94)90161-9

Related Literature

Article Analysis
・Effects of amoxapine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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