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Long-term effects of a treatment course with oral alendronate of postmenopausal osteoporosis.

Author: AdamiS, BragaV, DorizziR, GattiD, RossiniM, ZamberlanN

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This double-blind controlled study evaluated the duration of alendronate's effects in postmenopausal women with osteoporosis. Alendronate suppressed bone turnover and increased bone mineral density. These effects were sustained for 6 months after treatment withdrawal, but bone turnover eventually returned to pretreatment values.
Paper Details　
Original Abstract of the Article :
Several bisphosphonates are under investigation for the treatment and prevention of postmenopausal osteoporosis. Alendronate, one of these compounds, has been shown to inhibit bone turnover and induce substantial increases in bone mass, but little is known about the duration of its effects. This is ...See full text at original site
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引用元：
https://doi.org/10.1002/jbmr.5650091121

データ提供：米国国立医学図書館（NLM）

Long-Term Effects of Alendronate on Postmenopausal Osteoporosis: A Double-Blind Study

In the vast desert of bone health research, we often encounter the shifting sands of osteoporosis, a condition that weakens bones and increases fracture risk. This study, a double-blind controlled trial, delves into the long-term effects of alendronate, a medication used to treat postmenopausal osteoporosis. The researchers, like intrepid explorers, used alendronate as their compass to navigate the complexities of bone turnover and bone density.

The study found that alendronate significantly suppressed bone turnover markers within three months, but this effect waned after treatment withdrawal. While the lumbar spine bone mineral density (BMD) saw a positive increase during treatment, it didn't persist after the medication was stopped. This suggests that alendronate's benefits on bone density may be temporary, although more research is needed to fully understand the long-term impact.

Navigating the Sands of Bone Density: A Temporary Oasis?

The study's results highlight the complexity of bone health. Alendronate may provide a temporary oasis for bone density, but its effects may not be permanent. The study reminds us that maintaining bone health requires a holistic approach, taking into account lifestyle factors and ongoing medical management.

Bone Health: A Journey Through Time

As a fellow explorer of the human body, I find this study fascinating. The insights into bone turnover and the temporary nature of alendronate's effects remind us that maintaining bone health is a journey, not a destination. We must embrace a proactive approach to bone health, paying attention to diet, exercise, and regular medical checkups.

Dr. Camel's Conclusion

The study reveals that alendronate can effectively manage bone turnover and temporarily improve bone density. However, further research is needed to fully understand its long-term effects and to develop strategies for sustainable bone health.
Date :
  1. Date Completed 1995-03-20
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

7863833

DOI: Digital Object Identifier

10.1002/jbmr.5650091121

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in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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