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Safety of pentamidine prophylaxis for Pneumocystis carinii pneumonia on the endocrine pancreatic function in HIV patients.

Author: CevallosR, FarinottiR, GeffrayL, KaloustianE, Le Fouillé-RibeyreC, VeyssierP

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study assessed the pancreatic beta cell function of HIV patients receiving either aerosolized pentamidine or oral trimethoprim-sulfamethoxazole. Pancreatic function was preserved in pentamidine-treated patients compared to TMP-SMX-treated patients.
Paper Details　
Original Abstract of the Article :
We assessed the pancreatic beta cells function of HIV patients receiving either 300 mg per month of aerosolized pentamidine (n = 12) or oral trimethoprim-sulfamethoxazole (TMP-SMX), twice a day three times per week (TMP: 160 mg, SMX: 800 mg) (n = 10). Intravenous (i.v.) glucose tolerance tests were ...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/7864513

データ提供：米国国立医学図書館（NLM）

Safety of Pentamidine Prophylaxis for Pneumocystis carinii Pneumonia

This study examines the potential impact of pentamidine, a medication used to prevent Pneumocystis carinii pneumonia (PCP), on the endocrine pancreatic function of HIV patients. The researchers compared the effects of aerosolized pentamidine to oral trimethoprim-sulfamethoxazole (TMP-SMX), a standard prophylactic treatment for PCP. The goal was to determine whether pentamidine poses any risks to pancreatic function.

Navigating the HIV Desert: Balancing Treatment and Safety

The study's findings suggest that aerosolized pentamidine may be a safe and effective alternative to TMP-SMX for PCP prophylaxis in HIV patients, without significant adverse effects on pancreatic function. It's like navigating a desert landscape—while there may be different paths to take, it's essential to choose a route that is both safe and effective for reaching the desired destination.

HIV Treatment: A Journey Through the Desert

For individuals living with HIV, managing the disease requires a comprehensive and individualized approach. This study sheds light on the potential safety and efficacy of aerosolized pentamidine, offering a valuable option for PCP prophylaxis. It's like finding a reliable oasis in the vast desert of HIV treatment—a place where individuals can find safe haven and support while navigating the challenges of managing their health.

Dr.Camel's Conclusion

This study provides valuable information for healthcare providers managing HIV patients. It suggests that aerosolized pentamidine can be a safe and effective alternative to TMP-SMX for PCP prophylaxis, potentially offering patients a more convenient and well-tolerated treatment option.
Date :
  1. Date Completed 1995-03-23
  2. Date Revised 2018-12-17
Further Info :

Pubmed ID

7864513

DOI: Digital Object Identifier

7864513

Related Literature

Article Analysis
・Effects of pentamidine oral inhalation
SNS
PICO Info
in preparation
Languages

English

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