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Olsalazine versus sulphasalazine for relapse prevention in ulcerative colitis: a multicenter study.

Author: BennoP, BergmanL, DanielssonA, FausaO, FlorholmenJ, KarvonenA L, KildeboS, KollbergB, LöfbergR, NilssonA

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.

Overview

Olsalazine and sulphasalazine were equally effective in preventing relapse in patients with ulcerative colitis. Olsalazine was better tolerated, particularly regarding diarrhea.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To compare the relapse-preventing effect and the frequency of adverse events of olsalazine and sulphasalazine in sulphasalazine-tolerant patients with ulcerative colitis. METHODS: Patients in remission, with at least two episodes of active disease during the last 5 yr, were randomized to...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/7872274

データ提供：米国国立医学図書館（NLM）

Ulcerative Colitis: Comparing Olsalazine and Sulphasalazine

The digestive system is like a bustling marketplace, with a delicate balance of activity. Ulcerative colitis, a chronic inflammatory bowel disease, disrupts this balance, causing inflammation and ulceration in the colon. This study focuses on the efficacy of two medications, olsalazine and sulphasalazine, in preventing relapses of ulcerative colitis. It compared the relapse rates and side effect profiles of these medications in patients who had previously tolerated sulphasalazine. The results indicate that olsalazine and sulphasalazine have comparable relapse-preventing effects, with olsalazine demonstrating better tolerability, particularly regarding diarrhea. This research offers valuable insights into the treatment options for ulcerative colitis and their potential benefits and drawbacks.

Olsalazine: A Promising Option for Ulcerative Colitis

This study suggests that olsalazine could be a viable alternative to sulphasalazine for patients with ulcerative colitis. The similar efficacy and better tolerability, especially in terms of diarrhea, make it a promising option for those seeking relief from this debilitating condition.

Living with Ulcerative Colitis: A Desert Oasis of Relief

Ulcerative colitis can be a challenging condition, but this research offers a ray of hope. By comparing the effectiveness of olsalazine and sulphasalazine, it provides valuable information for patients and their physicians in making informed treatment decisions. This research underscores the importance of personalized medicine and tailoring treatment plans to meet individual needs.

Dr. Camel's Conclusion

Imagine a desert oasis, where travelers find relief from the scorching sun and thirst. This research is like a cool, refreshing spring within the desert of ulcerative colitis. It offers valuable information about the potential benefits and drawbacks of two treatment options. The knowledge gained from this study is like a precious resource for those seeking relief from ulcerative colitis, helping them navigate the challenges of this condition with a greater sense of hope and understanding.

Date :
  1. Date Completed 1995-03-30
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

7872274

DOI: Digital Object Identifier

7872274

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Article Analysis
・Side Effects of olsalazine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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