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Treatment of primary insomnia with trimipramine: an alternative to benzodiazepine hypnotics?

Author: BergerM, DressingH, HohagenF, LisS, MonteroR F, RiemannD, SchönbrunnE, WeissE

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Trimipramine, a sedating antidepressant, was found to be effective in treating insomnia, improving sleep efficiency and reducing wake time, with no evidence of rebound insomnia after discontinuation.
Paper Details　
Original Abstract of the Article :
A group of 19 middle aged patients suffering from primary insomnia according to the DSM-III-R were treated in a single-blind study with trimipramine, a sedating antidepressant. A total of 15 patients completed the study protocol and were evaluated. The present pilot study aimed at investigating the ...See full text at original site
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引用元：
https://doi.org/10.1007/BF02193521

データ提供：米国国立医学図書館（NLM）

A New Hope for Insomnia: Exploring Trimipramine as an Alternative to Benzodiazepines

Insomnia, a sleep disorder characterized by difficulty falling asleep or staying asleep, can have a significant impact on quality of life. This research investigates the effectiveness of trimipramine, a sedating antidepressant, as an alternative to benzodiazepine hypnotics for the treatment of primary insomnia. The researchers conducted a single-blind study involving patients with primary insomnia, analyzing sleep patterns and subjective sleep quality before, during, and after treatment with trimipramine.

Finding Relief from Insomnia: Trimipramine's Potential for Sleep Improvement

This study demonstrates the potential of trimipramine as a promising treatment option for insomnia. The researchers found that trimipramine significantly improved sleep efficiency, total sleep time, and stage 2 sleep percentage, while reducing wake time and stage 1 sleep percentage. These findings suggest that trimipramine may be a valuable alternative to benzodiazepines for patients seeking relief from insomnia.

Navigating the Sleep Landscape: A Holistic Approach to Sleep Disorders

This research highlights the importance of a holistic approach to sleep disorders, considering both pharmacological and non-pharmacological interventions. While trimipramine may offer relief for some individuals, lifestyle modifications such as regular sleep schedules, relaxation techniques, and avoidance of caffeine and alcohol can also play a significant role in promoting healthy sleep habits.

Dr. Camel's Conclusion

This study, like a desert traveler finding solace in a cool spring, offers hope for individuals struggling with insomnia. The findings suggest that trimipramine may be a viable treatment option for those seeking relief from sleep disturbances. This research underscores the importance of exploring a range of approaches to address the complexities of sleep disorders.

Date :
  1. Date Completed 1994-12-22
  2. Date Revised 2019-11-01
Further Info :

Pubmed ID

7948056

DOI: Digital Object Identifier

10.1007/BF02193521

Related Literature

Article Analysis
・Side Effects of trimipramine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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