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Effects of pimozide on cognition in children with Tourette syndrome: interaction with comorbid attention deficit hyperactivity disorder.

Author: RockC M, SalleeF R, SethuramanG

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

This study investigated the effects of pimozide and haloperidol on cognitive function in children with Tourette syndrome (TS). Pimozide was more effective than haloperidol and improved memory search efficiency compared to no treatment.
Paper Details　
Original Abstract of the Article :
Pimozide, a dopamine receptor antagonist, dopamine uptake inhibitor and L-type calcium channel blocker, is used in children suffering from Tourette syndrome (TS), but its effect on frequently comorbid attention deficit hyperactivity disorder (ADHD) is unknown. We have characterized the cognitive eff...See full text at original site
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引用元：
https://doi.org/10.1111/j.1600-0447.1994.tb01546.x

データ提供：米国国立医学図書館（NLM）

Pimozide: A Potential Oasis in the Desert of Tourette Syndrome

Tourette syndrome (TS) is a neurological disorder characterized by involuntary movements and vocalizations. This study explores the effects of pimozide, a medication used to treat TS, on cognitive function in children with TS, particularly those with comorbid attention deficit hyperactivity disorder (ADHD).

The researchers conducted a study comparing the effects of pimozide, haloperidol, and no medication on cognitive function in children with TS. They found that pimozide treatment was superior to haloperidol and improved memory search efficiency compared to the no-drug condition. They also found that pimozide was particularly beneficial for children with comorbid ADHD.

Pimozide: A Potential Benefit for Children with TS and ADHD

This study provides encouraging evidence for the potential of pimozide in treating TS and its associated cognitive challenges. It suggests that pimozide may be a valuable option for children with TS, especially those with comorbid ADHD, who often struggle with attention, memory, and other cognitive functions.

Navigating the Desert: Managing TS and ADHD

Managing TS and ADHD can be a challenging journey, like traversing a vast and unforgiving desert. This study offers a potential oasis of hope, highlighting the potential benefits of pimozide in improving cognitive function and quality of life for children with these conditions. However, as always, it is crucial to consult with a healthcare professional to determine the most appropriate treatment plan for each individual.

Dr.Camel's Conclusion

This study provides valuable insights into the potential of pimozide in improving cognitive function in children with TS, particularly those with comorbid ADHD. While further research is needed to confirm these findings, this study suggests that pimozide may be a promising treatment option for this population.

Date :
  1. Date Completed 1994-11-28
  2. Date Revised 2019-08-15
Further Info :

Pubmed ID

7976448

DOI: Digital Object Identifier

10.1111/j.1600-0447.1994.tb01546.x

Related Literature

Article Analysis
・Effects of pimozide
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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