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Should probenecid be used to reduce the dicloxacillin dosage in orthopaedic infections? A study of the dicloxacillin-saving effect of probenecid.

Author: HansenB A, JensenP, KrogsgaardM R, SlotsbjergT

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Dicloxacillin is an antibiotic used to treat orthopaedic infections. Lowering the dosage from 500 mg to 250 mg three times a day with probenecid may be as effective as the higher dose while reducing cost and side effects.
Paper Details　
Original Abstract of the Article :
Reduction in the dosage of dicloxacillin from 500 mg to 250 mg 3 times a day would mean lowering of costs and less side-effects in orthopaedic infections. In this cross-over study, the serum concentrations of dicloxacillin were measured in 9 patients after administration of dicloxacillin 500 mg 3 ti...See full text at original site
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引用元：
https://doi.org/10.1111/j.1600-0773.1994.tb01096.x

データ提供：米国国立医学図書館（NLM）

Exploring the Synergistic Effects of Dicloxacillin and Probenecid

Dicloxacillin, a potent antibiotic, is often used to treat orthopaedic infections. However, high doses can lead to side effects and increased costs. This study investigates the potential of using probenecid, a drug that prolongs the action of antibiotics, to reduce the necessary dose of dicloxacillin, much like discovering a new oasis that allows for a shorter journey across the desert while still reaching the destination.

Probenecid: A Partner in Antibiotic Therapy

The researchers compared the serum concentrations of dicloxacillin when administered alone and when combined with probenecid. They discovered that administering probenecid alongside a lower dose of dicloxacillin produced similar drug levels in the blood, indicating that probenecid effectively prolongs the antibiotic's action, potentially allowing for a lower overall dosage. This could potentially reduce costs and side effects without compromising therapeutic effectiveness.

Balancing Efficacy and Safety

This research presents a fascinating approach to optimizing antibiotic therapy, suggesting that combining drugs can enhance efficacy while potentially reducing side effects. However, it's important to remember that the use of antibiotics should always be guided by a healthcare professional. They can help determine the appropriate dosage and duration of treatment based on individual needs.

Dr. Camel's Conclusion

This study offers an intriguing strategy for improving antibiotic treatment, potentially reducing costs and side effects. Further research is needed to fully understand the implications of this approach, but it underscores the importance of finding innovative ways to optimize medication regimens.

Date :
  1. Date Completed 1994-07-21
  2. Date Revised 2019-09-04
Further Info :

Pubmed ID

8008725

DOI: Digital Object Identifier

10.1111/j.1600-0773.1994.tb01096.x

SNS
PICO Info
in preparation
Languages

English

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