Anxiety psychopathology predictive of outcome in patients with panic disorder and depression treated with imipramine, alprazolam and placebo.

Author: DeltitoJ A, KellerM B, LeonA, OttoM W, PollackM H, RosenbaumJ F, SachsG S, ShearM K

Paper Details 
Original Abstract of the Article :
This study examines clinical predictors of outcome for patients with panic disorder and depression in a 16 week, placebo-controlled trial of alprazolam and imipramine (n = 126). Baseline global severity of illness and phobic avoidance were differentially predictive of acute response to treatment. Pa...See full text at original site
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引用元:
https://doi.org/10.1016/0165-0327(94)90134-1

データ提供:米国国立医学図書館(NLM)

Unraveling the Mysteries of Anxiety in Panic Disorder and Depression

Anxiety, like a persistent desert wind, can wreak havoc on our mental well-being. This study delves into the psychological landscape of panic disorder and depression, investigating the predictive power of anxiety psychopathology on treatment outcomes. The researchers employed a placebo-controlled trial with two promising medications, alprazolam and imipramine, to unravel the intricacies of anxiety's impact on these conditions.

The Influence of Anxiety on Treatment Response: A Delicate Balance

The study reveals a fascinating interplay between anxiety and treatment response. Patients with mild to moderate levels of global distress experienced greater improvement with imipramine compared to alprazolam. Interestingly, higher levels of phobic avoidance were associated with reduced effectiveness of active medications compared to placebo. This suggests that anxiety, like a desert mirage, can distort our perception of reality and influence the success of treatment.

Managing Anxiety in Panic Disorder and Depression: A Holistic Approach

This study underscores the importance of addressing anxiety in the management of panic disorder and depression. Patients with higher levels of phobic avoidance may require additional support and targeted interventions to optimize treatment outcomes. Just as a traveler in the desert needs to navigate carefully to avoid mirages, patients with anxiety need a comprehensive approach that includes medication, therapy, and lifestyle adjustments to effectively manage their condition.

Dr.Camel's Conclusion

This research, like a caravan traversing a vast desert, reveals the intricate relationship between anxiety and treatment outcomes in panic disorder and depression. It highlights the need for a multifaceted approach that addresses both the psychological and biological aspects of these conditions. Just as a wise traveler prepares for the challenges of the desert, we must be prepared to address the complexities of anxiety in our quest for mental well-being.

Date :
  1. Date Completed 1994-07-22
  2. Date Revised 2019-09-04
Further Info :

Pubmed ID

8014326

DOI: Digital Object Identifier

10.1016/0165-0327(94)90134-1

Related Literature

SNS
PICO Info
in preparation
Languages

English

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