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The effect of nebulised pentamidine on the concentration of intra-oral Candida albicans in HIV-infected patients.

Author: AitchisonT C, LameyP J, MacFarlaneT W, NolanA, ShawJ, SirelJ Y

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Pentamidine therapy was associated with lower concentrations of Candida albicans in the oral cavity of HIV-infected patients, suggesting its potential role in prophylaxis against oral candidiasis.
Paper Details　
Original Abstract of the Article :
This prospective study investigated whether oral candidal carriage in HIV-infected patients was altered by pentamidine therapy. Repeated oral rinses were taken from 56 HIV-positive patients over a 2-year period. Oral candidal carriage was investigated in two groups of patients, one receiving prophyl...See full text at original site
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引用元：
https://doi.org/10.1099/00222615-41-2-95

データ提供：米国国立医学図書館（NLM）

Pentamidine: A Local Prophylactic Agent for Oral Candidiasis in HIV-Infected Patients

Oral candidiasis is a common opportunistic infection in HIV-infected patients. This study investigates the effectiveness of nebulized pentamidine in reducing the concentration of Candida albicans in the oral cavity of HIV-positive patients.

Pentamidine's Protective Effects

The study found that patients receiving pentamidine therapy had significantly lower concentrations of Candida albicans in their mouths compared to those not receiving prophylaxis. This suggests that pentamidine may be a valuable prophylactic agent for preventing oral candidiasis in HIV-infected patients. The study's findings highlight the importance of using local agents to target specific sites of infection.

Managing Oral Candidiasis in HIV Patients

The study underscores the need for effective strategies to prevent and manage oral candidiasis in HIV-infected patients. The research provides strong evidence for the effectiveness of pentamidine as a local prophylactic agent, emphasizing the importance of incorporating preventative measures into the overall management of HIV infection.

Dr.Camel's Conclusion

This study explores the use of nebulized pentamidine as a local prophylactic agent for oral candidiasis in HIV-infected patients. The study's findings provide compelling evidence for the effectiveness of pentamidine in reducing Candida albicans levels in the oral cavity, highlighting its potential as a valuable tool for preventing this common opportunistic infection in HIV-positive individuals.

Date :
  1. Date Completed 1994-09-01
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

8046740

DOI: Digital Object Identifier

10.1099/00222615-41-2-95

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Languages

English

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