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High dose toremifene in advanced breast cancer resistant to or relapsed during tamoxifen treatment.

Author: HajbaA, PyrhönenS, ValavaaraR, VuorinenJ

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

High-dose toremifene was generally well tolerated, with a response rate of 4% in patients with advanced breast cancer refractory to tamoxifen therapy. However, a subgroup of patients who had achieved complete response during tamoxifen therapy experienced a longer progression-free time with toremifene.
Paper Details　
Original Abstract of the Article :
Fifty patients with advanced breast cancer refractory to prior tamoxifen therapy were assigned to investigational treatment with high-dose toremifene administered 120 mg orally twice a day. Treatment was generally well tolerated. The majority (80%) of the patients had no side effects, and among the ...See full text at original site
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引用元：
https://doi.org/10.1007/BF00666475

データ提供：米国国立医学図書館（NLM）

High-Dose Toremifene: A New Hope for Tamoxifen-Resistant Breast Cancer

Breast cancer is a complex disease, and finding effective treatments for patients with tamoxifen-resistant tumors remains a significant challenge. This study explores the use of high-dose toremifene, a selective estrogen receptor modulator, as a second-line hormonal therapy for patients whose breast cancer has progressed despite tamoxifen treatment. The study investigates the effectiveness and tolerability of high-dose toremifene in this challenging patient population.

Toremifene: A Potential Option for Tamoxifen-Resistant Breast Cancer

While the overall response rate to high-dose toremifene was modest, the study identified a subset of patients who had previously achieved complete responses to tamoxifen therapy and experienced longer progression-free survival with high-dose toremifene. This finding suggests that high-dose toremifene might be a valuable option for a select group of patients with tamoxifen-resistant disease. Further research is needed to refine patient selection criteria and optimize the use of high-dose toremifene in this context.

Tailoring Treatment for Breast Cancer

This study highlights the importance of personalized treatment strategies for breast cancer. Each patient's tumor biology and treatment history are unique, requiring careful evaluation and selection of the most appropriate therapy. Open communication with your oncologist and a collaborative approach to treatment are essential for optimizing your chances of successful breast cancer management.

Dr. Camel's Conclusion

Imagine a camel caravan encountering a sandstorm. Just as a driver must adapt their strategy to navigate the treacherous conditions, oncologists must tailor treatment to each patient's unique situation. This study suggests that for some patients, high-dose toremifene, like a strong camel with extra supplies, might provide the necessary support to overcome challenges and continue their journey toward recovery.

Date :
  1. Date Completed 1994-09-06
  2. Date Revised 2019-09-04
Further Info :

Pubmed ID

8049456

DOI: Digital Object Identifier

10.1007/BF00666475

Related Literature

Article Analysis
・Side Effects of toremifene
SNS
PICO Info
in preparation
Languages

English

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