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Pharmacokinetics and local responses to submucosal meperidine compared with other routes of administration.

Author: BurckartG, HabuckyK, McKeeK C, NazifM M, SchmittM, VenkataramananR, ZulloT

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Meperidine was administered intravenously, submucosally, intramuscularly, and orally to 10 healthy adults. The IV and SM routes showed the fastest absorption with peak concentrations observed at 10 minutes, while IM and PO routes showed peak concentrations at 20 and 45 minutes, respectively. The IV and SM routes had similar plasma levels, while IM and PO routes had significantly lower peak values compared to IV and SM. The SM route caused more tissue response and pain, but the difference was not statistically significant.
Paper Details　
Original Abstract of the Article :
The objective of this study was to determine the time course of the plasma levels of meperidine administered by various routes. Ten healthy adults received 0.8 mg/kg of meperidine given intravenous, submucosal, intramuscular, and 1.4 mg/kg orally in a randomized sequence at a minimum of one-week int...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/8058542

データ提供：米国国立医学図書館（NLM）

Meperidine: A Look at Different Delivery Routes

Pain management is a crucial aspect of healthcare, and choosing the right delivery route for analgesics is essential. This study compared the pharmacokinetic profiles of meperidine, a commonly used opioid analgesic, when administered via intravenous, submucosal, intramuscular, and oral routes. The researchers used a randomized crossover design with ten healthy adults receiving meperidine at different doses and intervals. Blood samples were collected at various time points to determine the plasma levels of meperidine. The study found that intravenous and submucosal routes resulted in similar peak concentrations of meperidine, while intramuscular and oral routes resulted in lower peak concentrations.

Tailoring Pain Relief: Finding the Right Route

The results suggest that the choice of meperidine delivery route can significantly influence its pharmacokinetic profile. Intravenous and submucosal routes may provide faster and higher peak concentrations, potentially making them suitable for urgent pain management. However, the study also found that the submucosal route resulted in greater tissue response and pain reaction, highlighting the need for careful consideration of the potential side effects of different routes.

Navigating the Desert of Pain Relief: Choosing the Right Route

Choosing the right route for pain relief is like navigating a vast desert – each path offers its own advantages and disadvantages. Intravenous and submucosal routes may be effective for immediate pain relief, but other options might be more suitable for long-term pain management. It's important to consult with your healthcare provider to determine the best approach for your individual needs.

Dr.Camel's Conclusion

This study provides valuable insights into the pharmacokinetics of meperidine, offering a glimpse into the complexities of pain management. Like a camel navigating a desert, understanding the different routes and their effects is crucial for finding the path that leads to optimal pain relief.

Date :
  1. Date Completed 1994-09-12
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

8058542

DOI: Digital Object Identifier

8058542

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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