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Modulation of antiviral immune responses by exogenous cytokines: effects of tumour necrosis factor-alpha, interleukin-1 alpha, interleukin-2 and interferon-gamma on the immunogenicity of an inactivated rabies vaccine.

Author: ClaassenI J, HorzinekM C, OsterhausA D, SchijnsV E, VermeulenA A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Cytokines, such as TNF-alpha, IL-1 alpha, IL-2, and IFN-gamma, were investigated for their effects on the immune response to inactivated rabies virus vaccine in mice. While all cytokines enhanced antibody responses, IL-2 and IFN-gamma significantly increased vaccine protection against challenge infection. IFN-gamma also preferentially stimulated IgG2a production and augmented vaccine-induced splenocyte proliferation.
Paper Details　
Original Abstract of the Article :
In vivo administration of exogenous cytokines may influence elicited immune responses, and hence may change the efficacy of a vaccine. We investigated the effects of tumour necrosis factor-alpha (TNF-alpha), interleukin-1 alpha (IL-1 alpha), interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) on t...See full text at original site
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引用元：
https://doi.org/10.1099/0022-1317-75-1-55

データ提供：米国国立医学図書館（NLM）

Boosting the Immune Response to Rabies

Just as a camel's immune system helps it survive the harsh desert environment, our immune system protects us from various threats. This study investigates the potential of exogenous cytokines in boosting the immune response to the rabies virus. Like a skilled caravan leader guiding his camels across a treacherous desert, this research explores ways to strengthen our immune defenses against this deadly virus. The researchers studied the effects of various cytokines, including TNF-alpha, IL-1 alpha, IL-2, and IFN-gamma, on the immune response elicited by the rabies vaccine in mice.

Harnessing the Power of Cytokines

The study found that certain cytokines, particularly IFN-gamma and IL-2, significantly enhanced the immune response to the rabies vaccine. This discovery, like finding a hidden water source in the desert, opens up new possibilities for improving the efficacy of vaccines and providing stronger protection against rabies.

Strengthening Immunity and Protecting Health

The study's findings highlight the potential of cytokines to enhance our body's natural defenses against infectious diseases. This research provides valuable insights into the complex workings of the immune system and can lead to the development of more effective vaccines and therapies to protect our health.

Dr. Camel's Conclusion

This study reveals the potential of specific cytokines to enhance the immune response to rabies vaccination. This research offers exciting possibilities for strengthening our defenses against this dangerous virus and improving the efficacy of vaccines.

Date :
  1. Date Completed 1994-03-29
  2. Date Revised 2008-11-21
Further Info :

Pubmed ID

8113740

DOI: Digital Object Identifier

10.1099/0022-1317-75-1-55

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Article Analysis
・Effects of rabies vaccine
SNS
PICO Info
in preparation
Languages

English

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